Spinal Muscular Atrophy (SMA) is a genetic disease seen in Maine Coon cats. The disease is characterized by progressive instability with unsteady gait and posture abnormalities due to loss of motor neurons in the lower spinal cord and atrophy of muscles in the hind limbs.

2005年3月1日 · This report describes the clinical, pathologic, and genetic features of juvenile-onset SMA in a family of purebred domestic cats that is phenotypically homologous to the mild forms of SMA in...

2021年1月4日 · Spinal Muscular Atrophy, also known as SMA, is a neurodegenerative disorder that can occur in a variety of cat breeds, including Maine Coons. It causes the neurons that travel to the skeletal muscles of a cat’s hind limbs and torso to degenerate until the cat is …

Spinal Muscular Atrophy is a genetic condition that impacts the muscles and nerves in a cat’s body. Imagine it as a communication breakdown where the nerves struggle to tell the muscles what to do, leading to weakness and movement issues. For Maine Coons, SMA can make it tough for them to move around as they grow.

2023年4月6日 · Spinal Muscular Atrophy (SMA) is a genetic disorder affecting the spinal cord’s motor neurons. It is a rare condition that can cause muscle weakness and atrophy in affected cats. Maine Coon cats, in particular, are known to be predisposed to SMA.

Spinal Muscular Atrophy (SMA) is a hereditary disorder in which the nerve cells that control the skeletal muscles of the trunk and limbs are affected. The disease is transmitted autosomal recessive, i.e. it is not sex-linked and both parents must be carriers. They transmit the disease without suffering from it themselves.

Signs: muscle weakness and atrophy, progressive unsteady gait. Diagnosis: DNA testing, definitive diagnosis made post-mortem. Treatment: none. Prognosis: signs are progressive although affected cats do seem to stabilize and most live very comfortably as indoor cats for many years. First apparent at 3-4 months of age.

Spinal muscular atrophy is a condition that currently has been discovered only in Maine Coon Cats. This disorder affects muscular movement and can lead to disability. Cats that are born with this condition can survive and lead healthy lives, despite the disability to motor functionality.

ACTA2（actin alpha 2）是一种肌动蛋白，有多个别名，包括α-肌动蛋白、α-肌动蛋白-2、主动脉平滑肌或α平滑肌肌动蛋白 (α-SMA)。 Actins是球状多功能蛋白质的一个家族，形成微丝。

SMA is a disorder caused by death of spinal cord neurons that activate skeletal muscles of the trunk and limbs. Loss of neurons in the first few months of life leads to muscle weakness and atrophy that first becomes apparent at 3-4 months of age.