Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. [5][6] SMC1A is a subunit of the cohesin complex which …

SMC1A related Developmental and Epileptic Disorder. X-linked variants in the SMC1A gene cause Loss-of-Function in gene expression. This always results in Developmental Impairment …

The SMC1A gene provides instructions for making a protein that is part of the structural maintenance of chromosomes (SMC) family. Learn about this gene and related health conditions.

2024年12月25日 · SMC1A (Structural Maintenance Of Chromosomes 1A) is a Protein Coding gene. Diseases associated with SMC1A include Cornelia De Lange Syndrome 2 and …

Every human has SMC1A gene in their body’s cells. This gene is responsible for producing SMC1A protein that’s critical for healthy and appropriate cell function. The SMC1 protein is …

Among SMCs, SMC1A gene is unique. It encodes a subunit of the cohesin-core complex that tethers sister chromatids together to ensure correct chromosome segregation in both mitosis …

SMC1A facilitates gastric cancer cell proliferation, migration, and invasion via promoting SNAIL activated EMT. PIK3R3 is upregulated in liver cancer and activates Akt signaling to control …

The SMC1A gene encodes a component of the cohesin complex which controls chromosome segregation in both mitosis and meiosis. • SMC1A participates in DNA damage response, …

2020年6月15日 · Among SMCs, SMC1A gene is unique. It encodes a subunit of the cohesin-core complex that tethers sister chromatids together to ensure correct chromosome segregation in …

Clinical resource with information about SMC1A, Congenital muscular hypertrophy-cerebral syndrome, Developmental and epileptic encephalopathy, 85, with or without midline brain …

These results suggest that SMC1A is a novel proliferation regulator that promotes the growth of lung cancer cells, and that down-regulation of SMC1A expression induces growth suppression …

2025年1月17日 · Structural maintenance of chromosome-1A (SMC1A) is overexpressed in various malignancies including triple-negative breast cancer (TNBC). As a core component of …

SMC1 (Structural Maintenance of Chromosomes protein 1), well known as one of the SMC superfamily members, has been explored to function in many activities including chromosome …

2020年6月15日 · Among SMCs, SMC1A gene is unique. It encodes a subunit of the cohesin-core complex that tethers sister chromatids together to ensure correct chromosome segregation in …

The cohesin multiprotein complex is required for sister chromatid cohesion, a prerequisite for the correct segregation of chromosomes during cell division, and is composed partly of two …

The SMC1A gene provides instructions for making a protein that is part of the structural maintenance of chromosomes (SMC) family. Within the nucleus, SMC proteins help regulate …

The core of the complex consists of four subunits; SMC1A, SMC3, RAD21, and STAG1/2. Loss-of-function mutations in many of these proteins have been implicated in human developmental …

2023年6月28日 · Pathogenic variants in genes encoding cohesin complex structural subunits and regulatory proteins (NIPBL, SMC1A, SMC3, HDAC8, and RAD21) are the major pathogenic …

SMC1A knockdown attenuates sphere formation and sensitizes prostate cancer cells toward x-irradiation. A, SMC1A expression was detected by 48 h after irradiation by qRT-PCR in NT …

In addition, this evolutionarily conserved protein complex plays an integral role in DNA replication, DNA repair, and the regulation of transcription. The core complex is composed of four …