Dec 25, 2024 · SMC4 (Structural Maintenance Of Chromosomes 4) is a Protein Coding gene. Diseases associated with SMC4 include Pleural Empyema and Meningioma, Familial. Among its related pathways are Cell Cycle, Mitotic and RNA Polymerase I Promoter Opening.

The structural maintenance of chromosome 4 (SMC4) is a member of the ATPase family of chromosomes. The most widely reported function of SMC4, as well as the remaining subunits of whole condensin complexes, is compression and dissociation of sister ...

Mar 16, 2023 · Structural maintenance of chromosome 4 (SMC4), a member of the chromosome ATPase family, is a class of proteins evolutionarily conserved from bacteria to humans (1).

Sep 30, 2016 · Structural maintenance of chromosome 4 (SMC4) is a core subunit of condensin complexes that mainly contributes to chromosome condensation and segregation. Our previous study demonstrated...

Feb 9, 2025 · Study found that mRNA expression of SMC4 was upregulated in invasive breast cancer cells. Patients with high mRNA level of SMC4 suffered different survival with triple negative breast cancer (TNBC) and non-TNBC. These results suggest that SMC4 could be a good biomarker for predicting the prognosis.

Mar 13, 2017 · Our results provide new insight into the oncofunction of SMC4 and the mechanism by which the TGFβ/Smad pathway is hyperactivated in gliomas, indicating that SMC4 is a valuable prognostic factor...

SMC4 could be a potential biomarker for prognosis and immune cell infiltrates in sarcoma. Methods: Several databases including ONCOMINE, GEPIA, and Kaplan-Meier Plotter were adopted to explore the expression pattern of SMC4 in sarcoma, which was confirmed by IHC.

SMC-4, also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog, is a protein encoded by the SMC4 gene in humans. SMC-4 is a crucial subunit of condensin I and II, large protein complexes involved in high-order chromosome organization, including condensation and segregation.

Mar 14, 2025 · SMC4 was an independent prognostic factor for the prognosis of HCC. To examine the role of SMC4 in HCC, gene expression data from the GSE14520 dataset were analyzed.

Here, we establish a multifarious role for SMC4 in the switching of colorectal cancer cells to a diapause-like state. SMC4 attenuation promotes the expression of three investment phase glycolysis enzymes increasing lactate production while also suppressing PGAM1.