Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. [5][6][7][8] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family. This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex.

2024年12月25日 · Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1.

SuperMemeGuardian1 and SuperMemeGuardian2, abbreviated as SMG1 and SMG2 or colloquially as One and Two, are two of the three overarching protagonists (alongside SMG0) of the SMG4 series.

该基因编码一种参与无义介导的 mRNA 衰变 (NMD) 的蛋白质，作为 mRNA 监视复合体的一部分。 该蛋白具有激酶活性，被认为通过磷酸化无义转录物调节蛋白 1 在 NMD 中发挥作用。 已经描述了选择性剪接的转录物变体，但它们的全长性质尚未确定。 [RefSeq 提供，2013 年 3 月] This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex.

We report here that smg - 1, which is required for NMD in C. elegans, encodes a protein kinase of the phosphatidylinositol kinase superfamily of protein kinases. We identify null alleles of smg - 1 and demonstrate that SMG-1 kinase activity is required in vivo for NMD and in vitro for SMG-2 phosphorylation.

2001年9月1日 · We show that a novel phosphatidylinositol 3-kinase-related protein kinase, hSMG-1, is a human ortholog of a product of Caenorhabditis elegans smg-1, one of seven smg genes involved in NMD. hSMG-1 phosphorylates hUPF1/SMG-2 in vivo and in vitro at specific serine residues in SQ motifs. hSMG-1 can associate with hUPF1/SMG-2 and other components ...

2019年11月23日 · SMG 1是一种410 KDa蛋白，属于PHos phatidylinositol 3-激酶相关激酶家族 (PIKKs)，包括细胞生长的主调节因子mTOR，以及参与DNA损伤反应的三种主要调节因子ATM、ATR和DNA PKcs。 SMG1结构. 在人体细胞中，SMG1与两个NMD效应子形成复合物SMG8和SMG9抑制SMG1激酶活性体外。 SMG9直接结合SMG1，而SMG8结合SMG1仅在SMG9的存在下。 C.elegans的SMG8-SMG9晶体结构核心复合物显示SMG8-SMG9异源二聚体形成通过C-末 …

【摘 要】SMG-1 (suppressor with morphogenetic effect on genitalia-1,SMG-1)是新发现的磷脂酰肌醇-3-激酶相关激酶 (the phosphoinositide 3-kinase-related kinase,PIKKs)家族成员,因其参与无义介导的mRNA降解 (nonsense-mediated mRNA decay,NMD)途径,在基因毒性应激反应中维持基因组稳定性,并参与细胞 ...

SMG1 编码一个丝裂原活化蛋白激酶激酶OsMKK4，包含一个丝氨酸/苏氨酸蛋白激酶结构域。 smg1 表现出直立密穗、籽粒变小变轻，粒长显著降低，粒宽轻微降低，株高稍微变矮的表型（Duan et al. 2014）。 抑制 OsMKK4 表达，可使得水稻穗着粒变密以及籽粒变小（Guo et al. 2018）。 图位克隆表明， OsMKK4 基因 (Os02g0787300)的突变导致 smg1 的表型（Duan et al. 2014）。 实时定量PCR表明 SMG1 在发育的穗和种子中表达， SMG1 启动子驱动GUS实验 …

2009年5月1日 · SMG-8 and SMG-9 suppress SMG-1 kinase activity in the isolated SMG-1 complex and are involved in NMD in both mammals and nematodes. SMG-8 recruits SMG-1 to the mRNA surveillance complex, and inactivation of SMG-8 induces accumulation of a ribosome:Upf1:eRF1:eRF3:EJC complex on mRNP, which physically bridges the ribosome and EJC through eRF1 ...