
XBP1 induces snail expression to promote epithelial- to …
2015年1月1日 · In this study, we report findings that human X-box binding protein1 (XBP1) acts as a novel regulator of EMT. We found that increased expression of XBP1 was associated …
上皮间质转化(EMT)4种标志物介绍 - 知乎 - 知乎专栏
SNAI1 的锌指结构可与 E-cadherin 等 靶基因启动子 上游区域的 E-box 特异性结合并抑制 靶基因启动子活性使其表达降低从而诱导 EMT 过程。 上皮间质转化(epithelial-mesenchymal …
LOXL2 drives epithelial-mesenchymal transition via activation …
2017年3月23日 · LOXL2-dependent IRE1-XBP1 activation induces the expression of several EMT-TFs: SNAI1, SNAI2, ZEB2 and TCF3 that are direct transcriptional targets of XBP1. …
Cellular EMT-status governs contact guidance in an electrospun …
2025年2月1日 · Expression levels of E-cadherin (CDH1) and Vimentin (VIM) and mRNA levels of the EMT transcription factors SNAI1 and XBP1 (X-box binding protein 1) were monitored. …
The emerging role of XBP1 in cancer - ScienceDirect
2020年7月1日 · Oncogenic MYC interacts with XBP1 by targeting the IRE1/XBP1 pathway of the UPR in breast cancer to enhance its transcriptional activity; hyperactivated MYC is …
O35426 - UniProt
Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the …
Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to
2018年1月25日 · Importantly, expression of miR-153 was induced by hypoxia-stimulated ER stress, which activates IRE1α and its downstream transcription factor X-box binding protein 1 …
XBP1 Induces Snail Expression to Promote Epithelial- to
2014年9月30日 · In this study, we report findings that human X-box binding protein1 (XBP1) as a novel regulator of EMT. We found that increased expression of XBP1 was associated with the …
Roles of X-box binding protein 1 in liver pathogenesis
X-box binding protein 1 (XBP1) is a distinct transcription factor with a basic-region leucine zipper structure, whose activity is regulated by alternative splicing in response to disruptions in …
Genomic targets of the IRE1-XBP1s pathway in mediating …
In addition to binding core mesenchymal transcription factors SNAI1 and ZEB1, we observed that hexosamine biosynthetic pathway (HBP) enzymes were induced and contained proximal …