2015年1月1日 · In this study, we report findings that human X-box binding protein1 (XBP1) acts as a novel regulator of EMT. We found that increased expression of XBP1 was associated with the progression of breast cancer and that XBP1 protein was significantly over-expressed in matched metastatic tumor.

SNAI1 的锌指结构可与 E-cadherin 等 靶基因启动子 上游区域的 E-box 特异性结合并抑制 靶基因启动子活性使其表达降低从而诱导 EMT 过程。 上皮间质转化（epithelial-mesenchymal transition，EMT）是上皮细胞向间充质细胞转化的一个过程，上皮细胞失去顶基细胞极性，失去粘附性并获得间充质细胞的表型，获得间充质细胞迁移能力以促进转移和耐药性。 EMT…

2017年3月23日 · LOXL2-dependent IRE1-XBP1 activation induces the expression of several EMT-TFs: SNAI1, SNAI2, ZEB2 and TCF3 that are direct transcriptional targets of XBP1. Remarkably, inhibition of IRE1 blocks LOXL2-dependent upregulation of EMT …

2025年2月1日 · Expression levels of E-cadherin (CDH1) and Vimentin (VIM) and mRNA levels of the EMT transcription factors SNAI1 and XBP1 (X-box binding protein 1) were monitored. Snail is known to downregulate CDH1 and upregulate VIM [29], while XBP1 has been recently linked to EMT and metastasis, impacting cancer progression and therapy outcomes [30].

2020年7月1日 · Oncogenic MYC interacts with XBP1 by targeting the IRE1/XBP1 pathway of the UPR in breast cancer to enhance its transcriptional activity; hyperactivated MYC is synthetically lethal when combined with XBP1 inhibition [52].

Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the emerging XBP1 polypeptide chain, as part of a mRNA-ribosome-nascent chain (R-RNC) complex, cotranslationally recruits its own unprocessed mRNA through transient ...

2018年1月25日 · Importantly, expression of miR-153 was induced by hypoxia-stimulated ER stress, which activates IRE1α and its downstream transcription factor X-box binding protein 1 (XBP1). X-box binding protein...

2014年9月30日 · In this study, we report findings that human X-box binding protein1 (XBP1) as a novel regulator of EMT. We found that increased expression of XBP1 was associated with the progression of breast...

X-box binding protein 1 (XBP1) is a distinct transcription factor with a basic-region leucine zipper structure, whose activity is regulated by alternative splicing in response to disruptions in endoplasmic reticulum (ER) homeostasis and the unfolded protein response (UPR) activation.

In addition to binding core mesenchymal transcription factors SNAI1 and ZEB1, we observed that hexosamine biosynthetic pathway (HBP) enzymes were induced and contained proximal XBP1s peaks. We demonstrate that IRE1α -XBP1s signaling is necessary and sufficient to activate core enzymes by recruiting elongation-competent phospho-Ser2 CTD ...