2015年1月1日 · In this study, we report findings that human X-box binding protein1 (XBP1) acts as a novel regulator of EMT. We found that increased expression of XBP1 was associated …

SNAI1 的锌指结构可与 E-cadherin 等 靶基因启动子 上游区域的 E-box 特异性结合并抑制 靶基因启动子活性使其表达降低从而诱导 EMT 过程。 上皮间质转化（epithelial-mesenchymal …

2017年3月23日 · LOXL2-dependent IRE1-XBP1 activation induces the expression of several EMT-TFs: SNAI1, SNAI2, ZEB2 and TCF3 that are direct transcriptional targets of XBP1. …

2025年2月1日 · Expression levels of E-cadherin (CDH1) and Vimentin (VIM) and mRNA levels of the EMT transcription factors SNAI1 and XBP1 (X-box binding protein 1) were monitored. …

2020年7月1日 · Oncogenic MYC interacts with XBP1 by targeting the IRE1/XBP1 pathway of the UPR in breast cancer to enhance its transcriptional activity; hyperactivated MYC is …

Plays a role in the unconventional cytoplasmic splicing processing of its own mRNA triggered by the endoplasmic reticulum (ER) transmembrane endoribonuclease ERN1: upon ER stress, the …

2018年1月25日 · Importantly, expression of miR-153 was induced by hypoxia-stimulated ER stress, which activates IRE1α and its downstream transcription factor X-box binding protein 1 …

2014年9月30日 · In this study, we report findings that human X-box binding protein1 (XBP1) as a novel regulator of EMT. We found that increased expression of XBP1 was associated with the …

X-box binding protein 1 (XBP1) is a distinct transcription factor with a basic-region leucine zipper structure, whose activity is regulated by alternative splicing in response to disruptions in …

In addition to binding core mesenchymal transcription factors SNAI1 and ZEB1, we observed that hexosamine biosynthetic pathway (HBP) enzymes were induced and contained proximal …