选择性神经损伤模型（Spared nerve injury,SNI）是比较常用的外周神经损伤致痛敏的动物模型，其机械性痛敏出现早、持续时间长，手术操作比较简单，在动物造模中较CCI、SNL等有一定优势

保留神经损伤(sni)模型诱发神经性疼痛的症状，如 机械性异位痛 ，即由触觉刺激引起的疼痛，通常不会引起疼痛反应。 SNI小鼠模型包括结扎坐骨神经三个分支中的两个（胫神经和腓总神经），而腓肠神经保持完整的。

2018年3月20日 · The spared nerve injury (SNI) model in rodents is a partial denervation model, in which the common peroneal and tibial nerves are injured, producing consistent and reproducible tactile hypersensitivity in the skin territory of the spared, intact sural nerve.

We describe detailed surgical procedures to establish the SNI mouse model that has been widely used for investigating mechanisms of neuropathic pain. Keywords: Mouse pain model, SNI surgery, Peripheral nerve injury, Sciatic nerve, Neuropathic pain.

2003年10月1日 · Sparing the tibial branch of the sciatic nerve (ie, cutting the common peroneal and sural branches) produced the greatest and most reproducible reduction in nociceptive threshold. We find the SNI model in the mouse to be highly reproducible with respect to both behavioral and anatomic changes.

2011年8月18日 · The spared nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia i.e. pain due to tactile stimuli that do not normally provoke a painful response [1]. The SNI mouse model involves ligation of two of the three branches of the sciatic nerve (the tibial nerve and the common peroneal nerve), while the sural ...

2023年2月8日 · By imaging neuronal activity in a spared nerve injury (SNI) mouse model of neuropathic pain, we show that neurons in dorsal root ganglia (DRG) and somatosensory cortex (S1) exhibit synchronized...

2025年3月11日 · Systemic administration of the selective HDAC6 inhibitor ACY-1215 (20 mg/kg/day, 14 days), alleviated SNI-induced pain in mice of both sexes. ACY-1215 increased acetylated signal transducer and activator of transcription 3 (Ac-STAT3) and reduced phosphorylated STAT3 (p-STAT3) in the lumbar spinal cord of SNI mice.

在大鼠的备用神经损伤（SNI）模型中，腓总神经和胫骨神经受到了损伤，在备用腓肠神经区域产生了一致且可再现的疼痛超敏反应。 在这项研究中，我们调查了小鼠SNI是否也是神经性疼痛的有效模型系统。 SNI导致SNI手术小鼠的戒断阈值显着降低。 动物之间的效果非常一致，并持续了四个星期的研究。 我们还确定了11根冯·弗雷毛系列中每根毛的缩回爪的相对频率。 使用综合所有因素（神经损伤，爪，性别，和时间）显示了SNI随时间的变化非常稳定，并且还揭示了变量之 …

2022年1月25日 · Spared nerve injury (SNI) is an animal model that mimics the cardinal symptoms of peripheral nerve injury for studying the molecular and cellular mechanism of neuropathic pain in mice and rats.