2018年3月20日 · The spared nerve injury (SNI) model in rodents is a partial denervation model, in which the common peroneal and tibial nerves are injured, producing consistent and reproducible tactile hypersensitivity in the skin territory of the spared, intact sural nerve.

We describe detailed surgical procedures to establish the SNI mouse model that has been widely used for investigating mechanisms of neuropathic pain. Keywords: Mouse pain model, SNI surgery, Peripheral nerve injury, Sciatic nerve, Neuropathic pain

保留神经损伤(sni)模型诱发神经性疼痛的症状，如 机械性异位痛 ，即由触觉刺激引起的疼痛，通常不会引起疼痛反应。 sni小鼠模型包括结扎坐骨神经三个分支中的两个（胫神经和腓总神经），而腓肠神经保持完整的。

选择性神经损伤模型（Spared nerve injury,SNI）是比较常用的外周神经损伤致痛敏的动物模型，其机械性痛敏出现早、持续时间长，手术操作比较简单，在动物造模中较CCI、SNL等有一定优势

2011年8月18日 · The spared nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia i.e. pain due to tactile stimuli that do not normally provoke a painful response [1]. The SNI mouse model involves ligation of two of the three branches of the sciatic nerve (the tibial nerve and the common peroneal nerve), while the sural ...

2003年10月1日 · Sparing the tibial branch of the sciatic nerve (ie, cutting the common peroneal and sural branches) produced the greatest and most reproducible reduction in nociceptive threshold. We find the SNI model in the mouse to be highly reproducible with respect to both behavioral and anatomic changes.

Abstract: Mouse genetics has contributed significantly to our understanding of molecular mecha-nisms underlying tissue and nerve injury–induced persistent pain. To create a highly reproducible, relatively noninvasive model of neuropathic pain in the mouse, we …

选择性神经损伤模型（spared nerve injury，SNI）是一种比较常用的外周神经损伤致痛敏的动物模型，即神经性疼痛模型，其机械性痛敏出现早、持续时间长，手术操作也比较简单【6】。首先，作者通过对SNI后不同时间点的小鼠DRG进行了单细胞转录组分析，共发现了9 ...

2023年9月22日 · 小鼠雌雄分组后分别进行单侧或双侧SNI（spared nerve injury）手术，并于第3天（急性疼痛发展阶段），第14天（疼痛发展的亚慢性阶段）及第5个月（神经性疼痛的慢性阶段）收集小鼠新鲜脊髓样本，流式分选后进行scRNA-seq；共检测到188787个小胶质细胞，UMPA分 …

2025年1月22日 · Utilizing the spared nerve injury (SNI) model in mice, the research investigates the role of astrocytes and the excitatory neurotransmitter glutamate in chronic pain. The findings reveal that...