保留神经损伤 (SNI)模型诱发神经性疼痛的症状，如 机械性异位痛，即由触觉刺激引起的疼痛，通常不会引起疼痛反应。 SNI小鼠模型包括结扎坐骨神经三个分支中的两个（胫神经和腓总神经），而腓肠神经保持完整的。

Peripheral neuropathic pain is a severe chronic pain condition which may result from trauma to sensory nerves in the peripheral nervous system. The spared nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia i.e. pain due to tactile stimuli that do not normally provoke a painful response [1].

2011年8月18日 · Peripheral neuropathic pain is a severe chronic pain condition which may result from trauma to sensory nerves in the peripheral nervous system. The spared nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia i.e. pain due to tactile stimuli that do not normally …

The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development.

选择性神经损伤模型（Spared nerve injury,SNI）是比较常用的外周神经损伤致痛敏的动物模型，其机械性痛敏出现早、持续时间长，手术操作比较简单，在动物造模中较CCI、SNL等有一定优势

The spared nerve injury (SNI) model involves partial nerve injury where the common peroneal and tibial nerves are injured, producing consistent and reproducible pain hypersensitivity in the territory of the spared sural nerve (Decosterd and Woolf, 2000; Shields et al., 2003 ).

选择性神经损伤模型 （spared nerve injury， SNI）是一种比较常用的外周神经损伤致痛敏的动物模型，即神经性疼痛模型，其机械性痛敏出现早、持续时间长，手术操作也比较简单【6】。

2022年8月1日 · Neuropathic pain has long-term consequences in affective and cognitive disturbances, suggesting the involvement of supraspinal mechanisms. In this study, we used the spared nerve injury (SNI) model to characterize the development of sensory and aversive components of neuropathic pain and to determin …

In SNI model of neuropathic pain is nowadays accepted that there is the participation of non-neuronal cells of the CNS (astrocytes, microglia). Meanwhile, recent findings indicate the cooperation of central and peripheral immune cells is crucial for the development of …

我们建立了大鼠SNI模型，发现与对照组相比，SNI组大鼠出现左后足跛行、拖步、缩爪样、舔足、自发抬脚、自噬等现象，MWT明显下降，发生了机械痛敏感化，且具有时间依赖性（P < 0.000 1， 图 1B），此结果与Decosterd等 [9] 建立经典SNI模型的表现一致，提示建模成功。