2024年12月25日 · SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N) is a Protein Coding gene. Diseases associated with SNRPN include Prader-Willi Syndrome and Angelman Syndrome. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Prader-Willi and Angelman syndrome.

Small nuclear ribonucleoprotein-associated protein N is a protein that in humans is encoded by the SNRPN gene. [4] [5] The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family.

Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. SNRPN gene is imprinted, with monoallelic expression from the paternal allele in fetal brain and heart, and in adult brain.

1992年年底，第四个印记基因——Snrpn（中文名比较长，是“小核核糖核蛋白相关蛋白N”(small nuclear ribonucleoprotein-associated protein N)），被斯图尔特·列夫(Stuart E. Leff)团队宣告发现了，在这之前，还有很多区域被发现存在印记，尽管没有鉴定出基因。

在 cpg 岛相关印记中心启动的转录变体可能是双顺反子的，并且还编码来自上游开放阅读框的 snrpn 上游阅读框蛋白 (snurf) 。 此外，小核仁 RNA 宿主基因 14 (SNHG14) 的长剪接转录本可能源自该位点的启动子并与该基因共享外显子。

2016年7月19日 · We found that SNRPN regulated the expression level of Nr4a1, a critical nuclear receptor during neural development, in cultured primary cortical neurons. The abnormal spine development caused by...

SNRPN, or SNURF-SNRPN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The SNRPN gene is transcribed exclusively from the paternally inherited chromosome and shows highest expression in brain and heart.

2025年1月4日 · HIV-1 Vpr is identified to have a physical interaction with small nuclear ribonucleoprotein polypeptide N (SNRPN) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses

在CpG岛相关印记中心起始的转录变异体可能是双顺反子的，并从上游开放阅读框编码SNRPN上游阅读框蛋白（SNURF）。 此外，小核仁RNA宿主基因14（SNHG14）的长剪接转录本可能起源于该位置的启动子，并与该基因共享外显子。 该区域的变异与亲本印记开关失败有关，这可能导致天使人综合征或Prader-Willi综合征。 [RefSeq，2017年3月提供] Dir./Indir. 该模块正在开发中，请耐心等待我们的数据更新。 Analysis of the DNA sequence and duplication history of human …

2012年10月26日 · It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein.