2016年1月1日 · The most studied family members, CIS, SOCS1, SOCS2 and SOCS3 are important regulators of the JAK-STAT pathway. Here, we focus on SOCS2 and review its …

In general, cytokine binding to a cognate receptor results in activation of the JAK/STAT pathway and induction of Socs gene transcription in a STAT-dependent manner. The SOCS proteins …

2024年7月1日 · A review of current research on the SOCS-JAK-STAT pathway reveals that studies on the mechanism by which SOCS regulates the JAK-STAT pathway to inhibit …

2023年12月9日 · SOCS2 is a classical negative regulator of the JAK/STAT signaling pathway, and several studies have shown that inactivation of SOCS proteins has a substantial impact …

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible …

The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other …

SOCS 家族成员是细胞因子可诱导的细胞因子受体负调节因子，通过 Janus 激酶/信号转导和转录通路 (JAK/STAT 通路) 的激活进行细胞因子受体信号传导。 SOCS 家族蛋白与信号复合物的 …

SOCS2 inhibits Janus kinase 2 (Jak2) activity and Jak2-STAT3 binding. SOCS2 expression is necessary for STAT3 inhibition by c-Src inhibitors. Overexpression of SOCS2 is adequate to …

2024年12月25日 · SOCS2 (Suppressor Of Cytokine Signaling 2) is a Protein Coding gene. Diseases associated with SOCS2 include Hematologic Cancer and Polycythemia Vera. …

2008年9月4日 · Confirming that SOCS2 operates as a negative JAK2V617F regulator, SOCS2 knockdown induced constitutive STAT5 phosphorylation in JAK2 mu cells. CpG island …