An Updated Meta-Analysis of the Association between SORL1 Variants and the Risk for Sporadic Alzheimer's Disease. J Alzheimers Dis. 2013;37(2):429-37. PubMed. Pallesen LT, Vægter CB. …

SORLA, the sortilin-related receptor with type-A repeats, also known by its gene name SORL1 and as LR11, is an endosomal sorting receptor involved in APP and Aβ trafficking, among …

2025年1月17日 · SORL1 is responsible for returning CIMPR back to the TGN to pick up more proteases. Without it, the delivery system fails, and critical enzymes miss their ride (image …

2022年1月11日 · SORL1 cDNA downstream of the cytomegalovirus early enhancer/chicken β-actin promoter and a floxed neomycin resistance cassette with a polyA stop element (neo-R) …

2018年6月8日 · SORL1 first turned up as an AD risk gene in GWAS studies (Rogaeva et al., 2007), and SNPs in or around the gene were found to associate with AD in multiple ethnic …

2020年6月2日 · Scientists have linked loss-of-function mutations in SORL1 to overproduction of Aβ and to early onset Alzheimer’s disease. Now, in the June 2 Cell Reports, researchers led …

2023年7月18日 · SORL1’s dual membership in the LDLR and VPS10p protein families means that it shares many homologous domains with other proteins. By aligning them, pinpointing …

2023年9月18日 · A528T is a common variant of SORL1 that has been shown to associate with a slightly increased risk of AD (~15 percent) in people of European ancestry and to segregate …

2024年7月18日 · Residue 2134 is located within the stalk region, a 16-amino acid stretch (amino acids 2122-212137) that acts as a spacer between the plasma membrane and SORL1’s …

2023年7月19日 · Effect of prioritized SORL1 missense variants supports clinical consideration for familial Alzheimer's Disease. 2023 Jul 16 10.1101/2023.07.13.23292622 (version 1) medRxiv. …