Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. [5][6][7][8] This gene encodes a member of the SOX (SRY -related HMG-box) family of transcription factors involved in the regulation of embryonic development and …

SOX10是神经嵴发育中的关键性转录因子，对于神经嵴祖细胞迁移中的存活及多能性（pluripotency）的维持非常重要。 SOX10突变可表现为 外周神经脱髓鞘 、 色素沉着缺陷 、 耳聋 、 先天性巨结肠。 这一系列症状（外周神经脱髓鞘【peripheral demyelinating neuropathy】、中枢性脱髓鞘性脑白质营养不良【central dysmyelinating leukodystrophy】、Waardenbury综合征【Waardenbury syndrome】、先天性巨结肠【Hirschsprung diesease】）常合称为“ PCWH ”。

2024年12月25日 · SOX10 (SRY-Box Transcription Factor 10) is a Protein Coding gene. Diseases associated with SOX10 include Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease and Waardenburg Syndrome, Type 2E. Among its related pathways are Cell junction organization and …

SOX10 belongs to a family of 20 SRY (sex-determining region Y)-related high mobility group box-containing (SOX) proteins, most of which contribute to cell type specification and differentiation of various lineages. The first clue that SOX10 is ...

SOX10 (Sry-related HMg-Box gene 10) is a key nuclear transcription factor in the differentiation of neural crest progenitor cells to melanocytes. It has been shown to be a sensitive and specific marker of malignant melanoma of multiple histologic types. We evaluated the immunohistochemical profile o …

Expression of Sox10 in entrapped non-neoplastic Schwann cells or melanocytes in various neoplasms has to be considered in diagnosing Sox10-positive tumors. The Sox10 antibody belongs in a modern immunohistochemical panel for …

Sox10 belongs to a family of transcription regulators characterized by a DNA-binding domain known as the HMG box. It plays fundamental roles in neural crest development, peripheral gliogenesis, and terminal differentiation of oligodendrocytes.

SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells. SOX10 Regulates Melanoma Immunogenicity through an IRF4-IRF1 Axis. Cytokeratin 7, GATA3, and SOX-10 is a Comprehensive Panel in Diagnosing Triple Negative Breast Cancer Brain Metastases.

SOX10 serves as a crucial regulator of melanoma invasion and survival by influencing the expression of key factors such as MIA (melanocyte inhibitory activity), MITF, p21/WAF1, and E2F1; The absence of SOX10 expression has been linked to a reduction in melanoma formation, and silencing SOX10 leads to the elimination of tumor formation in vivo;

该基因编码参与胚胎发育调控和细胞命运决定的转录因子 SOX (SRY 相关 HMG 盒) 家族成员。 编码的蛋白质在与其他蛋白质形成蛋白质复合物后可以充当转录激活剂。 这种蛋白质充当核质穿梭蛋白，对神经嵴和周围神经系统的发育很重要。 该基因的突变与 Waardenburg-Shah 和 Waardenburg-Hirschsprung 病有关。 [RefSeq 提供，2008 年 7 月]