2024年12月25日 · SOX18 (SRY-Box Transcription Factor 18) is a Protein Coding gene. Diseases associated with SOX18 include Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome and Hypotrichosis-Lymphedema-Telangiectasia Syndrome .

Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene. [5][6] This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate.

Natural mutations in the Sox18 gene have been shown to result in cardiovascular dysfunction, in some cases leading to death. Available evidence thus implicates Sox18 as an important regulator of vascular development, most likely playing a key role in endothelial cell specification.

近年研究证实,SOX18的异常表达也参与了多种肿瘤的发生、发展及转移,本文总结了SOX18的功能特性及其在肿瘤中的研究进展。 Sex determining region Y box (SOX) 18 is a member of the SOX family of transcription factors. SOX18 is crucial for cardiogenesis,angiogenesis,and lymphangiogenesis during embryonic development. The mutation or aberrant expression of SOX18 is involved in many diseases.

2008年12月1日 · Overexpression of Sox18 in blood vascular endothelial cells induces them to express Prox1 and other lymphatic endothelial markers, while Sox18-null embryos show a complete blockade of lymphatic...

Identification of HCC-intrinsic factors regulating the immunosuppressive microenvironment is urgently needed. Here, we aimed to elucidate the role of SYR-Related High-Mobility Group Box 18 (SOX18) in inducing immunosuppression and to validate novel combination strategies for SOX18-mediated HCC progression and metastasis.

SRY-related HMG-box 18 (SOX18) is an important transcription factor involved in angiogenesis, tissue injury, wound-healing, and in embryonic cardiovascular and lymphatic vessels development. The role of angiogenic transcription factors, SOX18 and the related, prospero homeobox 1 (PROX1) and chicken ovalbumin upstream promoter transcription ...

2012年1月23日 · Mutations in the transcription factor SOX18 are responsible for specific cardiovascular defects in humans and mice. In order to gain insight into the molecular basis of its action, we identified target genes of SOX18 and analyzed one, MMP7, in detail.

该基因编码参与胚胎发育调控和细胞命运决定的转录因子 SOX (SRY 相关 HMG 盒) 家族成员。 编码的蛋白质在与其他蛋白质形成蛋白质复合物后可以充当转录调节剂。 这种蛋白质在毛发、血管和淋巴管发育中发挥作用。 该基因的突变与少毛症-淋巴水肿-毛细血管扩张症的隐性和显性形式有关。 [RefSeq 提供，2008 年 7 月]

The SOX18 gene (SRY-BOX Transcription Factor 18) (OMIM* 601,618) encodes a transcription factor in the SOX family, which is involved in the regulation of embryonic development and in the determination of the cell fate. From: European Journal of Medical Genetics, 2022