2022年11月7日 · Our study shows that for a functioning endolymphatic system in the inner ear, SOX9 regulates Sox10, and depending on the cell type and target gene, it works either independently of or cooperatively with SOX10.

The transcription factor Sox9 has been implicated in inner ear formation in several species. To investigate the long-term consequences of Sox9 depletion on inner ear development we analyzed the inner ear architecture of Sox9-depleted Xenopus tadpoles generated by injection of increasing amounts of Sox9 morpholino antisense oligonucleotides.

2005年11月1日 · In Xenopus, Sox9 is the earliest marker of the newly induced otic placode, which will give rise to the inner ear, and morpholino-mediated depletion of Sox9 leads to a failure of inner ear formation (Saint-Germain et al., 2004). The effects of upregulating SoxE activity on inner ear development have yet to be reported.

Sox9-null and heterozygous Sox10-null mutants, we implicate essential roles for both SOXE factors in hearing and vestibular function. Early in inner ear development, both SOX9 and SOX10 control ProgC differentiation and ionic homeostasis for a functioning endolymphatic system of the inner ear. The SOXE

In the otic placode, Sox9 colocalizes with Pax8 one of the earliest gene expressed in response to otic placode inducing signals. Depletion of Sox9 protein in whole embryos using morpholino antisense oligonucleotides causes a dramatic loss of …

Here we describe in detail, the expression pattern of SOX9 in the developing mouse inner ear beyond the otocyst stage and compare it with that of SOX2 from E9.5 to E18.5 using double fluorescence immunohistochemistry. We found that SOX9 was widely expressed in the otic epithelium, periotic mesenchyme and cartilaginous otic capsule.

SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms

2022年11月16日 · Our study shows that for a functioning endolymphatic system in the inner ear, SOX9 regulates Sox10, and depending on the cell type and target gene, it works either independently of or cooperatively with SOX10.

2022年12月14日 · 近日，一篇发表在国际杂志 Proceedings of the National Academy of Sciences 上题为“SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms”的研究报告中， 来自香港大学等机构的科学家们通过研究揭开了由内耳腔肿胀导致的耳聋的根本原因。 这项研究中，研究人员利用一种能显示耳聋的人类先天性疾病的小鼠模型进行研究，识别出了两个能控制听力功能的主要基因，这或许就为科学 …

2009年9月1日 · Here we describe in detail, the expression pattern of SOX9 in the developing mouse inner ear beyond the otocyst stage and compare it with that of SOX2 from E9.5 to E18.5 using double fluorescence immunohistochemistry. We found that SOX9 was widely expressed in the otic epithelium, periotic mesenchyme and cartilaginous otic capsule.