SP600125 | JNK Inhibitor - MedChemExpress
2014年11月27日 · SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to …
SP600125 - Cell Signaling Technology
Novel, potent, and selective JNK-1,-2, and -3 inhibitor, SP600125 is an ATP-competetive inhibitor effective on a range of kinases and enzymes. In cells, SP600125 caused a dose-dependent inhibition of the phosphorylation of c-Jun, the expression of inflammatory genes IL-2, COX-2, TNF-α, IFN-γ, and blocked the activation and differentiation of ...
SP600125 | 99.94%(HPLC) | In Stock | JNK inhibitor
SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. SP600125 is also a broad ...
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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
2001年11月20日 · We report the identification of an anthrapyrazolone series with significant inhibition of JNK1, -2, and -3 (K (i) = 0.19 microM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested.
SP600125, JNK inhibitor (CAS 129-56-6) (ab120065) - Abcam
SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflammatory genes COX-2, IL-2, IFNγ and TNFα.
SP600125 | STEMCELL Technologies
SP600125 is a potent and reversible inhibitor of JNK1-3 (IC₅₀ = 0.11 μM) (Bennett et al.). It is cell-permeable and dose-dependently inhibits c-JUN phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN- in T-cells (Bennett et al.).
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
2001年11月20日 · We report the identification of an anthrapyrazolone series with significant inhibition of JNK1, -2, and -3 (Ki = 0.19 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested.
SP600125, 98%, Thermo Scientific Chemicals - Thermo Fisher Scientific
SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 M.1 It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells.
SP600125 98 (HPLC) 1,9-Pyrazoloanthrone - MilliporeSigma
SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α. 8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke. 10
SP 600125 | JNK/c-Jun | Tocris Bioscience
SP 600125 is a selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40 - 90 nM) with negligible activity at ERK2, p38 β and a range of enzymes. Active in vivo. Exhibits reduced selectivity over other protein kinases under certain conditions.
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