NF-kB信号通路. NF-kB在细胞因子诱导的基因表达中起关键性的调控作用，它调控的基因编码急性期反应蛋白、细胞因子、细胞粘附分子、免疫调节分子、病毒瘤基因、生长因子、转录和生长调控因子等。

2024年3月4日 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the...

2003年2月3日 · Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR–mediated NF-κB activation and B cell development. Expression of the immunoglobulin heavy chain...

NF-κB （Nuclear Factor kappa-light-chain-enhancer of activated B cells）通路是一种在细胞信号传递中极为重要的途径，它在 调控免疫反应 、 炎症反应 、 细胞生长与死亡 等多种生理过程中起着关键作用。 这一通路能够响应多种刺激，包括 促炎细胞因子、自由基、紫外线辐射、细菌和病毒感染等，进而调控多种基因的表达。 NF-κB 是一组蛋白质复合体的统称，主要包含 RelA (p65)、 RelB 、 c-Rel 、 p50 / p105 (NF-κB1) 和 p52 / p100 (NF-κB2) 等亚单位。 在未被激活状态 …

2024年11月24日 · These findings suggest that an ethanol extract of Bletilla striata could be developed as a promising natural anti-inflammatory drug or health functional food with NF-κB pathway inhibitory activity. Syk/Src/NF-κB axis is essentially targeted in anti-inflammatory and anti-gastritis effects of Bletilla striata ethanol extract

2018年7月9日 · We showed that ALDH high (ALDH+) pancreatic cancer cells exhibited stem cell-like phenotype and expressed higher levels of FGFR1, Src, NF-κB, alongside stemness markers like Oct4 and Sox2, compared to their ALDH low/null (ALDH−) counterparts, suggesting the preferential activation of the FGFR1/Src/NF-κB signaling axis in pancreatic cancer ...

2024年3月4日 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the interaction of NF-κB signaling with other important pathways, including PI3K/AKT, MAPK, JAK-STAT, TGF-β, Wnt, Notch, Hedgehog, and TLR signaling.

The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death.

In this study, we investigated recruitment of coactivators (SRC-1, SRC-2, and SRC-3) and corepressors (HDAC1, HDAC2, HDAC3, SMRT, and NCoR) to the IkappaB alpha gene promoter after...

1997年12月1日 · Activation of NF-KB is mediated through the phosphorylation of its inhibitory subunit IKB, followed by the subsequent degradation of IKE at the proteasome. A second level of control involves phosphorylation events of NF-KB in the cell nucleus.