Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn ...
2021年10月26日 · Here, we investigated how the NLRP3 inflammasome is regulated. We found that its activation in primary mouse macrophages induced the Src family kinase Lyn to …
Src-family kinase-Cbl axis negatively regulates NLRP3 ... - Nature
2018年10月31日 · Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in suppressing NLRP3 inflammasome activation in response to stimulation by nigericin or ATP, …
Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn
2021年10月26日 · Here, we investigated how the NLRP3 inflammasome is regulated. We found that its activation in primary mouse macrophages induced the Src family kinase Lyn to …
Nintedanib attenuates NLRP3 inflammasome-driven liver fibrosis …
2024年12月25日 · Experiments in cell cultures and mice show that nintedanib inhibited NLRP3–IL-1β activation by Src/EGFR signaling. The discovery of this mechanism may lead to …
Tyrosine phosphatase SHP2 negatively regulates NLRP3 ... - Nature
2017年12月18日 · Here we show NLRP3 inflammasome stimulators trigger Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) translocation to the mitochondria, to …
Tyrosine Phosphorylation of NLRP3 by Src Family Protein Tyrosine …
2020年5月1日 · The NLRP3 inflammasome is a multi-protein complex that triggers the activation of inflammatory caspase-1 and the maturation of IL-1β in response ... Guoxin Lin, Hui Guo, …
Tyrosine Phosphorylation of NLRP3 by Src Family Protein Tyrosine …
2020年5月1日 · Here, we show that NLRP3 is tyrosine phosphorylated upon activation of the NLRP3 inflammasome, and that NLRP3 tyrosine phosphorylation correlates with its …
Src-family kinase-Cbl axis negatively regulates NLRP3 ... - PubMed
2018年10月31日 · Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in suppressing NLRP3 inflammasome activation in response to stimulation by nigericin or ATP, …
The NLRP3 Inflammasome Works as a Sensor for Detecting
2023年3月15日 · In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced NLRP3 inflammasome activation. Comprehensive analysis of the …
Tyrosine Phosphorylation of NLRP3 by Lyn Suppresses NLRP3 …
2017年5月1日 · Pretreating the macrophages with a specific Src kinase inhibitor inhibits NLRP3 tyrosine phosphorylation and ubiquitination, which leads to enhanced production of IL-1β. …