Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene. [5]

Sterol-regulatory element binding proteins (SREBPs)胆固醇调节元件结合蛋白(SREBP)是位于内质网的细胞内胆固醇敏感器，通过Insig-Srebp-Scap途径对细胞内胆固醇进行反馈调节。

Sterol regulatory element-binding proteins (SREBPs, including SREBP1a, SREBP1c, and SREBP2) are basic-helix-loop-helix leucine zipper (bHLH-Zip) transcription factors that regulate the synthesis and cellular uptake of two major building blocks of …

2021年1月15日 · 哺乳动物中，srebp有三种不同的形式，分别是srebp-1a, srebp-1c和srebp-2。 SREBP-1系列主要负责脂肪的从头合成，a和c在不同的组织中的表达谱不一样；SREBP-2主要负责胆固醇的代谢和稳态 【1,2】 。

SREBP有三个结构域：N-端细胞浆结构域，包含a basic helix-loop helix (bHLH) DNA-binding motif，当其从SREBP解离后入核，发挥转录因子的作用；中心膜锚定结构域，包含2次跨膜α螺旋；C-端细胞浆调控结构域。

REBP2 (sterol-regulatory element binding protein 2) is a key regulator of cholesterol homeostasis located in the endoplasmic reticulum to sense cholesterol changes. The expression and functions of SREBP2 are mainly regulated at three levels: (1)

SREBPs are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, …

2024年12月25日 · SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2) is a Protein Coding gene. Diseases associated with SREBF2 include Hypercholesterolemia, Familial, 1 and Bardet-Biedl Syndrome 18. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Metabolism of steroids.

Sterol-regulatory element-binding protein (SREBP)-2 is a key regulator of cholesterol. When cells are deprived of cholesterol, proteolytic cleavage releases the NH(2)-terminal domain of SREBP-2 that binds and activates the promoters of SREBP-2 …

胆固醇稳态对细胞功能和机体健康至关重要,胆固醇调节元件结合蛋白2 (sterol-regulatory element binding protein 2,SREBP2)是维持胆固醇稳态的关键调控因子,是一种位于细胞内质网的胆固醇敏感调节器.SREBP2的表达和功能主要受三个水平的调控: (1)SREBF2基因的转录调控, (2)SREBP2蛋白的转运与剪切调控, (3)nSREBP2的修饰及功能调控.该文系统地对上述三个阶段调控的研究进展及其在代谢性疾病中的作用进行了综述,这将为靶向SREBP2研究胆固醇代谢及其代谢异常相 …