Intra-operative stimulated Raman histology (SRH) is a novel technology which uses laser spectroscopy and color-matching algorithms to create images similar to formalin-fixed paraffin-embedded (FFPE) section. We aim to assess the accuracy of SRH in a novel range of sinonasal and skull base tumors.

2019年12月31日 · Here, we target unexplored skull base tumors using a fast simultaneous two-channel stimulated Raman scattering (SRS) imaging technique and a new pseudo-hematoxylin and eosin (H&E) recoloring ...

2022年3月30日 · Methods: We used a fiber laser-based, label-free, nonconsumptive, high-resolution microscopy method (<60 seconds per 1 × 1 mm2), called stimulated Raman histology (SRH), to image a consecutive, multicenter cohort of patients with skull base tumor.

2022年3月30日 · We used a fiber laser–based, label-free, nonconsumptive, high-resolution microscopy method (<60 seconds per 1 × 1 mm 2), called stimulated Raman histology (SRH), to image a consecutive, multicenter cohort of patients with skull base tumor.

We propose an innovative diagnosis system that uses a rapid (2–3 minutes, >10× speedup), label-free optical histology method, called stimulated Raman histology (SRH), combined with deep learning-based interpretation of fresh, unprocessed surgical specimens.

2019年12月31日 · Stimulated Raman histology (SRH), a label-free imaging technique for unprocessed biospecimens, has demonstrated promise in a limited subset of tumors. Here, we target unexplored skull base tumors using a fast simultaneous two-channel stimulated Raman scattering (SRS) imaging technique and a new pseudo-hematoxylin and eosin (H&E) recoloring ...

2019年12月6日 · Stimulated Raman histology (SRH) is a novel technology that allows for rapid acquisition of diagnostic histological images at the bedside. Methods: The authors performed a prospective blinded cohort study of 82 consecutive patients undergoing resection of CNS tumors to compare diagnostic time and accuracy of SRH simulation to the gold standard ...

SRH provides rapid assessment in a wide range of sinonasal and skull base pathologies including a spectrum of epithelial tumors. Larger number of cases and pathologists’ training are needed to fully validate SRH technology and to explore its potential to serve as an alternative to the standard intraoperative FS diagnosis.

2022年11月15日 · How accurate is intraoperative stimulated Raman histology (SRH) technology in producing images in a novel range of sinonasal and skull base tumors compared to formalin-fixed paraffin-embedded (FFPE) and hematoxylin and eosin (H&E)?

To examine the capability of SRH at providing useful histopathological information, we image a broad range of skull base tumors including nine meningiomas, three schwannomas, one chordoma, one chondrosarcoma, one pituitary adenoma, and one papillary craniopharyngioma.