The signal recognition particle RNA, (also known as 7SL, 6S, ffs, or 4.5S RNA) is part of the signal recognition particle (SRP) ribonucleoprotein complex. SRP recognizes the signal peptide and binds to the ribosome , halting protein synthesis.

信号识别颗粒signal recognition particle （SRP）在真核生物细胞质中一种小分子RNA和六种蛋白的复合体，此复合体能识别核糖体上新生肽末端的信号顺序并与之结合，使肽合成停止，同时它又可和ER（内质网）膜上的停泊蛋白识别和结合，从而将mRNA上的核糖体，带到膜 ...

The RNA core of the signal recognition particle (SRP), a highly conserved protein biogenesis machinery, is a suitable model system to study the co-transcriptional folding of RNA (Doudna and Batey, 2004; Keenan et al., 2001). This 114-nt SRP RNA from Escherichia coli is known to fold

2003年7月15日 · The signal recognition particle (SRP) is a ribonucleoprotein particle essential for the targeting of signal peptide‐bearing proteins to the prokaryotic plasma membrane or the eukaryotic endoplasmic...

Several observations suggest that SRP RNA is crucial to the function of the particle and is not simply a scaffold or an adaptor forming a bridge to another nucleic acid. In assays with purified...

The signal recognition particle (SRP) is an abundant, cytosolic, universally conserved ribonucleoprotein (protein-RNA complex) that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes.

In this review, we analyze the progress in studies of SRPs from different organisms, SRP biogenesis, its structure, and function in protein targeting and mRNA protection.

2024年12月11日 · SRP核心组件的保守性以及早期对SRP循环的基因和生物化学研究的结果，推断Srp68/72p异源二聚体的一个组分可用作Srp54p和SRα的GDS。 比较序列分析显示，来自不同物种的Srp54p同源物的蛋氨酸丰富的M区域具有类似最近鉴定的RNA识别基序的扩展区域。

The RNA component of the signal recognition particle (SRP) is universally required for cotranslational protein targeting. Biochemical studies have shown that SRP RNA participates in the central step of protein targeting by catalyzing the …

Signal recognition particle (SRP), which plays a critical role in the sorting of nascent secretory and membrane proteins, is a complex made of a RNA molecule of variable length and several proteins. (A) Plant cytoplasmic SRP is likely to be composed of six SRP proteins and a …