SRPK1 enables angiogenesis, which is regulated by VEGF, which either initiates or inhibits vessel formation depending on alternative splicing.

2024年12月25日 · SRPK1 (SRSF Protein Kinase 1) is a Protein Coding gene. Diseases associated with SRPK1 include Denys-Drash Syndrome and Lung Cancer. Among its related pathways are Infectious disease and Translation of Structural Proteins. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase activity.

2023年3月3日 · In brief, our research suggested that the SRPK1/GSK3β axis promotes gefitinib resistance by activating the Wnt pathway and may serve as a potential therapeutic target for overcoming gefitinib ...

Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme which moderates the activity of splicing factors rich in serine/arginine domains. Here we review SRPK1’s relationship with various cancers by performing a systematic review of all relevant published data.

2018年12月8日 · Serine/arginine protein kinase 1 (SRPK1); a versatile functional moonlighting protein involved in varied cellular activities comprised of cell cycle progression, innate immune response, chromatin reorganization, negative and positive regulation of viral genome replication, protein amino acid phosphorylation, regulation of numerous mRNA ...

SRPK1 promotes sepsis-induced acute lung injury via regulating PI3K/AKT/FOXO3 signaling. Inhibition of SRPK1, a key splicing regulator, exhibits antitumor and chemotherapeutic-sensitizing effects on extranodal NK/T-cell lymphoma cells.

Title: SRPK1 promotes cell proliferation and tumor growth of osteosarcoma through activation of the NF-κB signaling pathway. Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and …

Serine/arginine protein kinase 1 (SRPK1); a versatile functional moonlighting protein involved in varied cellular activities comprised of cell cycle progression, innate immune response, chromatin reorganization, negative and positive regulation of viral …

2023年3月6日 · 2023年3月4日，医学部基础医学院巩丽云教授课题组在Nature旗下杂志肿瘤学领域国际权威期刊Oncogene（中科院1区TOP期刊）在线发表题为“Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation...

2020年5月27日 · Inhibiting SRPK1 activity or enhancing its acetylation re-sensitises cells to cisplatin, suggesting a potential strategy to treat cancers resistant to platinum-based therapy.