SSE1 | SGD - Saccharomyces Genome Database
2006年2月7日 · SSE1 and SSE2 are two of nine cytosolic forms of HSP70 found in S. cerevisiae (SSA1, SSA2, SSA3, SSA4, SSB1, SSB2, SSE1, SSE2, SSZ1).SSE is the yeast homolog of …
A first-in-class inhibitor of Hsp110 molecular chaperones of
2023年5月12日 · Previously, we have solved the first X-ray crystal structure of a full-length Hsp110 using Sse1, revealing extensive NBD-SBD contacts in the ATP-bound state 54. In …
Sse1, Hsp110 chaperone of yeast, controls the cellular fate during ...
2024年4月5日 · Sse1 is a cytosolic Hsp110 molecular chaperone of yeast, Saccharomyces cerevisiae. Its multifaceted roles in cellular protein homeostasis as a nucleotide exchange …
Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role …
The yeast Hsp110 chaperone Sse1 is a conserved protein that is a noncanonical member of the Hsp70 protein superfamily. Sse1 influences the cellular response to heat stress and has also …
Interdomain interactions dictate the function of the
2021年9月1日 · In this study, we carried out biochemical analysis on Msi3, the sole Hsp110 in Candida albicans, to dissect the unique allosteric coupling of Hsp110s using three mutations …
Early Steps of Protein Disaggregation by Hsp70 Chaperone and
2024年9月20日 · In vivo studies on yeast chaperones demonstrated that the Hsp110 co-chaperone Sse1 plays a key role in Hsp70 recruitment to aggregates and is essential for …
Disease-associated mutations within the yeast DNAJB6 homolog
2022年8月5日 · Here, we show how mutations analogous to those found in LGMDD1 affect Sis1 (a functional homolog of human DNAJB6) function by altering the structure of client protein …
酵母Hsp110 Sse1在功能上与Hsp70伴侣Ssa和Ssb相互作用 …
Ssa1是酵母交配信息素α因子到内质网的翻译后易位的必需条件。像ssa突变体一样，我们证明sse1delta细胞会积累prepro-alpha因子，但不会共翻译导入蛋白质Kar2，这表明Sse1和Ssa之 …
Substrate binding by the yeast Hsp110 nucleotide exchange factor …
2017年5月24日 · Sse1 sbd retains nucleotide-binding and nucleotide exchange activities while exhibiting severe deficiencies in chaperone holdase activity for unfolded polypeptides. In …
The yeast Hsp110 Sse1 functionally interacts with the Hsp70
2005年12月16日 · Sse1 stimulated Ssa1 ATPase activity synergistically with the co-chaperone Ydj1, and stimulation required complex formation. Ssa1 is required for post-translational …