Objective: To report QT prolongation potential in selective serotonin reuptake inhibitors (SSRIs) in order to advise clinicians on safe use of SSRIs other than citalopram in light of citalopram warnings. Data sources: Primary literature and case reports were identified through a …

2015年11月16日 · Selective Serotonin Reuptake Inhibitors (SSRIs): There are published case reports linking all six currently available SSRIs (fluvoxamine, fluoxetine, paroxetine, sertraline, citalopram, and escitalopram) to QTc prolongation. 5 According to a recent meta-analysis of 16 articles representing all six currently available SSRIs, the SSRIs as a drug ...

QTc outcomes assessed included a prolonged QTc interval (>450 ms for men and >470 ms for women), and the mean change in QTc was adjusted for propensity score on SSRI use. SSRIs were not associated with a statistically significant increase in the incidence of QTc prolongation or a significantly prolonged QTc interval.

SSRIs were associated with a dose-dependent increase in QTc interval compared to placebo (+6.10 milliseconds; 95% CI, 3.47-8.73; P < .001). Tricyclic antidepressants (TCAs) were associated with a significantly greater QTc increase than SSRIs (TCA prolongation, 7.05 milliseconds; 95% CI, 3.84-10.27 greater than SSRIs; P < .001).

2018年3月26日 · Beach and colleagues 2 emphasize that SSRIs, including fluoxetine and paroxetine, are not statistically significantly associated with QT prolongation, as indicated by comprehensive, prospective studies regarding the corrected QT (QTc) interval. More caution should be used with escitalopram than with other SSRIs (excluding citalopram) because it ...

Post-marketing surveillance suggests that serotonin reuptake inhibitors and tricyclic antidepressants are associated with torsades de pointes (total of 662 cases) and QT prolongation (168 cases) in people taking antidepressants among other drugs.

Tricyclic Antidepressants and QTc •Tricyclic antidepressants –Affect sodium, calcium, and potassium channels –Generally are considered to be higher risk for QTc prolongation than SSRIs –Have other cardiovascular side effects as well

We explored the clinical background of QT interval prolongation related to serotonin selective reuptake inhibitors (SSRI) use and the clinical implications of safety issues. A review was conducted to clarify the mechanisms associated with the occurrence of TdP when using SSRI and investigating therapeutic measures to avoid/minimize these effects.

Aims: Selective serotonin re-uptake inhibitors (SSRIs), specifically citalopram and escitalopram, are thought to cause QTc prolongation, although studies have shown contradictory results. Nevertheless, a maximum citalopram dosage of 20 mg in high risk patients (e.g. >60 years of age) is recommended.

2020年11月3日 · The evidence to date suggests that citalopram (which increases QTc by about 10–20 msec) and escitalopram (which increases QTc by about 5–11 msec) carry the highest risk of QTc prolongation among second-generation antidepressants (e.g., selective serotonin reuptake inhibitors, selective norepinephrine reuptake inhibitors), while most other ...