TGF-β induces ST2 and programs ILC2 development - Nature
2020年1月7日 · In addition, TGF-β upregulates the expression of the IL-33 receptor gene Il1rl1 (encoding IL-1 receptor-like 1, also known as ST2) in ILC2p and common helper-like innate lymphoid progenitors...
Expansion of CD25 + Innate Lymphoid Cells Reduces Atherosclerosis
2015年10月22日 · We demonstrate that CD25 + ILCs that produce type 2 cytokines (ILC2s) are present in the aorta of atherosclerotic immunodeficient ldlr −/− rag1 −/− mice.
Non-redundant functions of group 2 innate lymphoid cells
2022年11月2日 · Here we report the generation of a mouse model based on the neuromedin U receptor 1 (Nmur1) promoter as a driver for simultaneous expression of Cre recombinase and green fluorescent protein, which...
ILC2 Cell Markers - R&D Systems
In mice, ILC2s have been described as Lin-Sca-1 + CD127 + CD117 + ST2 + ICOS + cells that also typically express CD90/Thy1, IL-17 RB, and CD25/IL-2 R alpha. In humans, ILC2s are commonly identified as Lin - CD127 + CD45 high CD161 + CRTH-2 …
Group 2 innate lymphoid cells protect lung endothelial cells …
2018年3月6日 · ILC2 in the lungs at baseline and time points up to 36 h after CLP or sham surgery (SS) were detected by flow cytometry and defined as Lin − CD45 + CD90.2 + ST2 + cells (see gating strategy in...
Lineage−Sca1+c-Kit−CD25+ Cells Are IL-33–Responsive Type 2 …
2011年12月1日 · In mice treated with IL-25 or IL-33, LSK − CD25 + cells significantly upregulated their expression of CD25 (p < 0.05) and ST2 (p < 0.01) but not IL-7Rα(Fig. 6B, 6C). In addition, we found that LSK − CD25 + cells express α 4 β 7 integrin and that its expression was also significantly upregulated on LSK − CD25 + cells after treatment ...
IL-33–Responsive Lineage−CD25+CD44hi Lymphoid ... - Oxford …
2012年2月1日 · D, Single-cell suspensions of lung cells from BALB/c and ST2 −/− mice were stained for lineage markers, CD44, CD25, and ST2. Top panels, Lin − lymphocytic cells were analyzed as described in Fig. 3A. Bottom panel, Expression of ST2 on Lin − CD25 + CD44 hi cells is depicted in BALB/c (black line) and ST2 −/− (gray line) mice.
Stage-specific GATA3 induction promotes ILC2 development after …
2024年7月5日 · Herein, we identify ILC2-specific GATA3-related tandem super-enhancers (G3SE) that induce high GATA3 in ILC2-committed precursors. G3SE-deficient mice exhibit ILC2 deficiency in the bone marrow,...
Lineage−Sca1+c-Kit−CD25+ Cells Are IL-33–Responsive Type 2 …
2011年12月1日 · Collectively, these results show that LSK − CD25 + cells are a unique population in the bone marrow that respond to in vivo IL-25 or IL-33 stimulation by increasing in frequency, number, and size and by upregulating the expression of CD25, ST2, and α 4 β 7 integrin.
Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in …
2017年12月1日 · When we specifically gated CD25 low ILC2s present in BAL fluid and lung from mice with HDM-driven inflammation, we found that these cells displayed low surface expression of ICOS, KLRG1, and T1/ST2 compared to gated CD25 high ILC2s.