在中国发现了K1血清型的碳青霉烯抗性ST23 hvKP，其blaKPC-2基因位于不可转移的质粒上。 典型的产生碳青霉烯酶的cKP（ST258）和K2 hvKP（ST65）之间的接合显示，携带 bla KPC-2或 bla KPC-3基因的质粒可以转移到hvKP中并保留在hvKP中。

2022年10月12日 · Herein, an analysis of four K. pneumoniae genomes, with a focus on the prevalent clone ST23-K1 hvKP, along with virulence and fitness assays revealed that the wcaJ gene is a potential factor that facilitates the combination of …

2018年7月7日 · “Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable blaDHA-1-carrying plasmid by an ST23...

2023年11月24日 · While many of the nosocomial S. epidermidis clones have strong capacities to form biofilms on artificial surfaces that protect them from anti-biotics and host defenses (19), the ST10, ST23, and ST87 clones are poor biofilm formers but alter their surfaces in a way that promotes their invasiveness (20).

目的分析肺炎克雷伯菌临床分离株K63 [第63号耐碳青霉烯类肺炎克雷伯菌 (CRKP)]的毒力耐药情况及全基因组特征.方法收集分离自宁夏某医院新生儿重症监护室男性患儿痰液标本的肺炎克雷伯菌K63株,通过VITEK 2 Compact对其进行鉴定和药物敏感性试验.PCR法检测菌株毒力基因 (ybtS,iutA,iucA,iroB,rmpA2,fimH,mrkD,peg344)和耐药基因 (bla_ (TEM),bla_ (SHV),bla_ (NDM),bla_ (IMP),bla_ (OXA-48),bla_ (VIM)).PacBio RSⅢ和illuminate高通量测序平台对其进 …

2023年5月16日 · Strain K-2157 exhibited resistance to carbapenems and was identified as a high-risk virulent clone belonging to capsular serotype K1 and sequence type 23 (ST23).

本研究采用经多位点序列分型(multilocus sequence typing, MLST)鉴定的临床肺炎克雷伯菌(Klebsiella pneumonia, KP) ST23菌株分别感染C57BL/6与MyD88KO小鼠，建立小鼠肺炎模型。对小鼠临床症状、肺菌载量与组织病理学变化进行时相性监测，并模拟ST23菌株感染对免疫抑制动物 …

In an urgent inquiry in ECDC’s Epidemic Intelligence Information System (EPIS) Antimicrobial Resistance and Healthcare-Associated Infections (AMR-HAI) platform, Ireland reported the isolation of hypervirulent Klebsiella pneumoniae (hvKp) ST23, from diagnostic samples and from rectal or faecal samples collected for the surveillance of carriage of...

摘要： 目的 本研究采用经多位点序列分型(multilocus sequence typing, MLST)鉴定的临床肺炎克雷伯菌 (Klebsiella pneumonia,KP) ST23菌株分别感染C57BL/6与MyD88KO小鼠,建立小鼠肺炎模型.对小鼠临床症状、肺菌载量与组织病理学变化进行时相性监测,并模拟ST23菌株感染对免疫抑制 ...

The current understanding of the drug resistance of ST23 Kp and infections caused by ST23 strains, particularly MDR strains, is insufficient. In this investigation, we sought to determine the molecular characteristics of ST23 Kp strains directly from second-generation-sequenced samples.