stat1是转录因子中信号转导及转录激活蛋白（stat蛋白）家族的一员。 STAT1涉及 I型 、 II型 或 III型 干扰素 激活基因的正调控。

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family. [5]

信号转导与转录激活因子 1 ( signal transducer and activator of transcription 1， STAT1) 是一种连接 细胞膜受体 与效应器间信号传导的重要蛋白。胞质中的 STAT1 在胞外信号的刺激作用下可发生磷酸 化并聚合形成同源或异源二聚体， 继而进入胞核促进靶基因转录 。

2024年12月25日 · STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency 31B. Among its related pathways are IL …

当stat被磷酸化后，发生聚合成为同源或异源二聚体形式的活化的转录激活因子，进入胞核内与靶基因启动子序列的特定位点结合，促进其转录。已克隆成功4种jak(jak13和tyk2)与7种stat(stat1，stat2，stat3，stat4，stat5a，stat5b，stat6)。

2022年11月14日 · 1、stat1-gof患者易患自身免疫性疾病，对真菌和病毒感染的易感性增加； 小鼠和人类的stat2 lof突变导致了对病毒的易感性增加。 2、stat3的lof突变是高免疫球蛋白 e（乔布氏）综合征的分子基础。

2021年11月26日 · The signal transduction and activator of transcription (STAT) family have six members: STAT1 (STAT1 has two splicing isoforms, STAT1α and STAT1β), STAT2, STAT3 (STAT3 has two splicing isoforms...

STAT1 is the major mediator of the cellular response to interferons (IFNs) [4,5]. It plays a key role in the immune response against viruses and mycobacteria by transducing in the nucleus the signal from type I IFNs (IFNα, IFNβ, IFNε, IFNκ, and IFNω), type II …

Mycobacterial And Viral Infections Due To Complete Stat1 Deficiency Immunodeficiency, Type 31b, Mycobacterial And Viral Infections, Autosomal Recessive Immunodeficiency 31c

2022年4月7日 · The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the immune response against viruses and other pathogens by transducing, in the nucleus, the signal from type I, type II and type III IFNs. STAT1 activates the transcription of hundreds of genes, some of which h …