
Targeting IFN/STAT1 Pathway as a Promising Strategy to …
Several preclinical studies have reported that the IFN/STAT1 pathway mediates radioresistance in the tumor microenvironment by shielding the immune responses and activating survival …
IFNγ induces JAK1/STAT1/p65 NFκB-dependent interleukin-8 ... - PubMed
The IFNγ-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFκB, and is associated with an increased occupancy of K314/315 acetylated p65 NFκB and Ser-727 …
IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive …
Pretreating cells with IFNβ or increasing the expression of U-STAT2 and IRF9 exogenously greatly enhances IL6 expression in response to the classical NF-κB activators IL1, TNF, and …
HDAC6 inhibitor ACY-1215 enhances STAT1 acetylation to block …
2024年1月17日 · In summary, our study showed that the HDAC6 inhibitor (ACY-1215) inhibits the entry of STAT1 and NF-κB p65 into the nucleus to exert transcriptional regulation on PD-L1 by …
IFNγ induces JAK1/STAT1/p65 NFκB-dependent ... - ScienceDirect
2021年12月1日 · The IFNγ-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFκB, and is associated with an increased occupancy of K314/315 acetylated p65 NFκB and …
Nucleic DHX9 cooperates with STAT1 to transcribe interferon
2023年2月3日 · Mechanistically, DHX9 interacts with STAT1 in the nucleus to recruit Pol II to participate in STAT1-mediated transcription and facilitate ISG expression to antagonize RNA …
NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription
2014年1月15日 · Mutation of a consensus NF-κB genomic sequence present in both gene promoters reduced the ability of IL-1β to promote transcription. In addition, IL-1β induced …
IFNγ induces JAK1/STAT1/p65 NFκB-dependent interleukin-8 …
Our results demonstrate that IFNγ induces IL-8 gene expression and chemokine release in OC cells. The IFNγ-induced IL-8 expression is mediated by both JAK1/STAT1 signaling and p65 …
IFNγ induces Bcl3 expression by JAK1/STAT1/p65 signaling
Here, we demonstrate that the IFNγ-induced Bcl3 expression is dependent on JAK1 and STAT1 signaling, and on p65 NFκB. Furthermore, the IFNγ-induced Bcl3 expression is associated …
IFNγ induces JAK1/STAT1/p65 NFκB-dependent ... - ScienceDirect
2021年12月1日 · Our results demonstrate that IFNγ induces IL-8 gene expression and chemokine release in OC cells. The IFNγ-induced IL-8 expression is mediated by both JAK1/STAT1 …