Several preclinical studies have reported that the IFN/STAT1 pathway mediates radioresistance in the tumor microenvironment by shielding the immune responses and activating survival signaling pathways. This review focuses on the oncogenic function of the IFN/STAT1 pathway, emphasizing the major signaling pathway in radiation sensitization.

The IFNγ-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFκB, and is associated with an increased occupancy of K314/315 acetylated p65 NFκB and Ser-727 phosphorylated STAT1 at the IL-8 promoter. Neutralization of IL-8 using anti-IL-8 antibody reduces IFNγ-induced migration of OC cells, and their invasion ability in 3D spheroids.

Pretreating cells with IFNβ or increasing the expression of U-STAT2 and IRF9 exogenously greatly enhances IL6 expression in response to the classical NF-κB activators IL1, TNF, and LPS. U-STAT2 binds tightly to IRF9, the DNA binding subunit of …

2024年1月17日 · In summary, our study showed that the HDAC6 inhibitor (ACY-1215) inhibits the entry of STAT1 and NF-κB p65 into the nucleus to exert transcriptional regulation on PD-L1 by promoting the acetylation of STAT1, leading to downregulation of PD-L1 expression and thus promoting the activation of T cells (Fig. 6). This study reveals a novel ...

2021年12月1日 · The IFNγ-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFκB, and is associated with an increased occupancy of K314/315 acetylated p65 NFκB and Ser-727 phosphorylated STAT1 at the IL-8 promoter. Neutralization of IL-8 using anti-IL-8 antibody reduces IFNγ-induced migration of OC cells, and their invasion ability in 3D spheroids.

2023年2月3日 · Mechanistically, DHX9 interacts with STAT1 in the nucleus to recruit Pol II to participate in STAT1-mediated transcription and facilitate ISG expression to antagonize RNA viruses. This study strengthens our understanding of the antiviral function of DHX9 and the ISG transcriptional machinery.

2014年1月15日 · Mutation of a consensus NF-κB genomic sequence present in both gene promoters reduced the ability of IL-1β to promote transcription. In addition, IL-1β induced binding of the p65 and p50 subunits of NF-κB to these consensus κB regulatory elements as well as to additional κB sites located near the core promoter regions of each gene.

Our results demonstrate that IFNγ induces IL-8 gene expression and chemokine release in OC cells. The IFNγ-induced IL-8 expression is mediated by both JAK1/STAT1 signaling and p65 NFκB. Neutralization of the induced IL-8 decreases migration of IFNγ-stimulated OC cells, and their invasion potential in 3D spheroids.

Here, we demonstrate that the IFNγ-induced Bcl3 expression is dependent on JAK1 and STAT1 signaling, and on p65 NFκB. Furthermore, the IFNγ-induced Bcl3 expression is associated with an increased occupancy of Ser-727 phosphorylated STAT1 and acetylated histone H3 …

2021年12月1日 · Our results demonstrate that IFNγ induces IL-8 gene expression and chemokine release in OC cells. The IFNγ-induced IL-8 expression is mediated by both JAK1/STAT1 signaling and p65 NFκB. Neutralization of the induced IL-8 decreases migration of IFNγ-stimulated OC cells, and their invasion potential in 3D spheroids.