Several preclinical studies have reported that the IFN/STAT1 pathway mediates radioresistance in the tumor microenvironment by shielding the immune responses and activating survival …

The IFNγ-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFκB, and is associated with an increased occupancy of K314/315 acetylated p65 NFκB and Ser-727 …

Pretreating cells with IFNβ or increasing the expression of U-STAT2 and IRF9 exogenously greatly enhances IL6 expression in response to the classical NF-κB activators IL1, TNF, and …

2024年1月17日 · In summary, our study showed that the HDAC6 inhibitor (ACY-1215) inhibits the entry of STAT1 and NF-κB p65 into the nucleus to exert transcriptional regulation on PD-L1 by …

2021年12月1日 · The IFNγ-induced IL-8 expression is dependent on JAK1, STAT1, and p65 NFκB, and is associated with an increased occupancy of K314/315 acetylated p65 NFκB and …

2023年2月3日 · Mechanistically, DHX9 interacts with STAT1 in the nucleus to recruit Pol II to participate in STAT1-mediated transcription and facilitate ISG expression to antagonize RNA …

2014年1月15日 · Mutation of a consensus NF-κB genomic sequence present in both gene promoters reduced the ability of IL-1β to promote transcription. In addition, IL-1β induced …

Our results demonstrate that IFNγ induces IL-8 gene expression and chemokine release in OC cells. The IFNγ-induced IL-8 expression is mediated by both JAK1/STAT1 signaling and p65 …

Here, we demonstrate that the IFNγ-induced Bcl3 expression is dependent on JAK1 and STAT1 signaling, and on p65 NFκB. Furthermore, the IFNγ-induced Bcl3 expression is associated …

2021年12月1日 · Our results demonstrate that IFNγ induces IL-8 gene expression and chemokine release in OC cells. The IFNγ-induced IL-8 expression is mediated by both JAK1/STAT1 …