Phospho-Stat3 (Tyr705) (D3A7) XP ® Rabbit mAb detects endogenous levels of Stat3 only when phosphorylated at tyrosine 705. This antibody does not cross-react with phospho-EGFR or the corresponding phospho-tyrosines of other Stat proteins.

2021年2月1日 · We assessed the IHC expression of phosphorylated STAT3 (pSTAT3) in paired primary tumors and liver metastases in patients with advanced stage colorectal cancer (CRC). We included patients with tissue blocks available from both the primary CRC and a surgically resected liver metastasis.

stat3是一个信号转导和转录激活子，介导细胞对白介素、kitlg/scf、lep和其他生长因子的反应。 一旦被激活，会 将共激活剂（例如NCOA1或MED1）募集到目标基因的启动子区域。

Polyclonal Antibody for studying STAT3. Validated for ChIP, IHC, IP, WB. Highly specific and rigorously validated in-house, Stat3 Antibody (CST #9132) is ready to ship.

2025年2月10日 · Mechanistically, osteopontin (OPN)/ITGB1 maintained the activation of nuclear factor κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) pathways by establishing a positive feedback loop with the CHI3L1-STAT3 axis, resulting in PMT.

2023年6月13日 · This study aimed to develop an immunohistochemistry (IHC)-based classifier using two commercially available antibodies targeting different phosphorylation sites of STAT3, namely Y705 and S727. The goal was to determine whether the phosphorylation status of these residues could serve as a biomarker for distinguishing between ALK - ALCL and CD30 ...

We assessed the IHC expression of phosphorylated STAT3 (pSTAT3) in paired primary tumors and liver metastases in patients with advanced stage colorectal cancer (CRC). Methods: We included patients with tissue blocks available from both the primary CRC and a surgically resected liver metastasis.

Stat3 (124H6) Mouse mAb detects endogenous levels of total Stat3 protein. Human, Mouse, Rat, Monkey. Monoclonal antibody is produced by immunizing animals with a synthetic peptide centered around amino acid Gln692 of human Stat3.

STAT3 signaling depended on GP130 as shown by strong reduction of epithelial p STAT3 levels upon GP130 shRNA-mediated knockdown in CRC cells. Materials and Reagents Paraffin sections (subcutaneous tumors samples or liver metastasis from nude mice respectively injected subcutaneously or intrasplenic with CRC cells)