Together, these findings indicate that the dynamic interaction between mTOR and STAT5 signaling modulates the reciprocal differentiation of the effective and regulatory T cells, and …

通过瞬时转染RNAi方法，分别对AKT1和STAT5基因进行基因沉寂，检测AKT1、STAT5和mTOR在mRNA和蛋白质表达以及活性磷酸化状态变化，并进一步综述对奶牛乳腺上皮细胞β …

2019年8月14日 · Here, we demonstrate that liver-specific activation of mTORC1 promoted the expression of lipid synthesis genes and lead to the development of spontaneous HCC. …

2015年1月1日 · STAT5 and mTOR signaling events differentially regulate effector and memory Tc cell survival, and a balance between the functions of these pathways may be required for …

2019年8月14日 · In conclusion, our data suggested that mTORC1 upregulates SREBP1 transcription via crosstalk with the STAT5 pathway which contributes to the NAFLD-related …

In conclusion, our data suggested that mTORC1 upregulates SREBP1 transcription via crosstalk with the STAT5 pathway which contributes to the NAFLD-related HCC pathogenesis. And the …

2018年2月23日 · 近日有研究人员通过scid小鼠、mtor缺陷小鼠、混合嵌合体小鼠和体外菌落形成以及单核/巨噬细胞诱导试验发现，抑制mtor可导致cd11b+f4/80+细胞的数量和比例降低，以 …

2022年11月25日 · STAT5 controlled transcription of members of the mTOR pathway to license T cells for IL-2–mediated mTOR signaling and promoted MYC-driven metabolic changes. …

2014年11月15日 · STAT5 and mTOR signaling events differentially regulate effector and memory Tc cell survival, and a balance between the functions of these pathways may be required for …

2015年4月1日 · In this study, we show that there is direct interaction between mTOR and STAT5 signaling in both Tregs and Teffs: mTOR inhibition weakens Teffs growth, but make Tregs shift …