Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. [5] . STAT5B orthologs [6] have been identified in most placentals for which complete genome data are available. The protein encoded by this gene is a member of the STAT family of transcription factors.

2024年12月25日 · STAT5B (Signal Transducer And Activator Of Transcription 5B) is a Protein Coding gene. Diseases associated with STAT5B include Growth Hormone Insensitivity Syndrome With Immune Dysregulation 1, Autosomal Recessive and Growth Hormone Insensitivity Syndrome With Immune Dysregulation 2, Autosomal Dominant.

2023年1月22日 · STAT5b activation is involved in the expression of genes that participate in cell development, proliferation, and survival. STAT5a and STAT5b are paralogs and only human mutations in STAT5B have been identified leading to immune dysregulation and hematopoietic malignant transformation.

信号转导和转录激活物（STAT）蛋白家族包括STAT1、STAT2、STAT3、STAT4、STAT5（STAT5A和STAT5B）和STAT6。 在癌症中， STAT蛋白，特别是STAT3和STAT5，作为细胞因子、生长因子及其受体和肿瘤细胞中过表达的其他分子转导信号，同时在转录水平和表观遗传水平上调节大量 ...

该蛋白介导由各种细胞配体触发的信号转导，例如 IL2、IL4、CSF1 和不同的生长激素。 它已被证明参与多种生物过程，例如 TCR 信号、细胞凋亡、成人乳腺发育和肝脏基因表达的性别二态性。 该基因被发现与一小部分急性早幼粒细胞白血病 (APLL) 中的视黄酸受体-α (RARA) 基因融合。 这种蛋白介导的信号通路失调可能是 APLL 的原因。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a member of the STAT family of transcription factors.

2025年1月21日 · STAT蛋白家族成员众多，在哺乳动物中已发现七种，包括STAT1、STAT2、STAT3、STAT4、STAT5a、STAT5b和STAT6。 这些成员在结构上具有高度相似性，均包含几个关键的功能区段：

信号转导与转录激活因子5b (signal transducer and activator of transcription 5b,STAT5b)主要参与介导细胞因子和生长因子对细胞信号转导作用.磷酸化的STAT5在细胞的增殖、分化、周期调控及凋亡过程中起重要作用,其过度活化导致细胞的异常增殖和凋亡障碍,促进肿瘤的发生 ...

2023年1月23日 · The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in immune regulation and homeostasis and play a crucial role in the development and function of several hematopoietic cells. STAT5b activation is involved in the expression of genes that participate in cell developme …

与人类 STAT5B（信号转导和转录激活因子 5B）直系同源。 [由基因组资源联盟提供，2022 年 4 月] Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; luteinization; and receptor signaling pathway via …

The STAT5B gene plays a role in the intracellular signaling pathway and also encodes a transcription factor. In response to growth hormone (GH1; 139250)/GHR (600946)-induced signaling, STAT5B mediates the synthesis of insulin-like growth factor-1 (IGF1; 147440), which plays an important role in postnatal somatic growth (summary by Hwa, 2016).