2024年12月25日 · STAT6 (Signal Transducer And Activator Of Transcription 6) is a Protein Coding gene. Diseases associated with STAT6 include Hyper-Ige Syndrome 6, Autosomal Dominant, With Recurrent Infections and Hemangiopericytoma, Malignant .

2024年8月27日 · In physiological state, cytokine stimulation and tyrosine phosphorylation of cytoplasmic STAT6 leads to transfer of STAT6 to nucleus for transcriptional roles in proliferation and immune regulation (Am J Clin Pathol 2015;143:672)

Signal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin(IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor.

Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is ...

STAT6 is a transcription factor and plays a predominant role in IL-4/IL-13 and virus-mediated signaling pathways. Extensive studies have linked malfunctions of STAT6 to pathological features of asthma and cancer. Targeting the function of STAT6 has become an attractive therapy.

2021年7月1日 · Signal Transducer and Activator of Transcription 6 (STAT6), belonging to a family of seven similar members is primarily stimulated by interleukin (IL)-4 and IL-13, and acts as a T helper type 2 (Th2)-inducing factor.

2021年11月26日 · There are 4 members in the JAK family: JAK1, JAK2, JAK3, and TYK2. The STAT family comprises seven members: STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6. We introduce them by family. JAK...

We developed a highly potent and selective oral STAT6 degrader, KT-621, and assessed its functions in vitro in human primary cells, and in vivo in intranasal house dust mite (HDM)-induced asthma models in both prophylactic and treatment regimens.

STAT6 is a survival factor in prostate cancer regulating the genetic transcriptional program for prostate cancer progression. The transcription factor STAT6 may play a pivotal role in the activation of eotaxin transcription in response to IL-4. STAT6 overexpression detected in a classical Hodgkins lymphoma cell line

Our STAT6 degraders showed potent STAT6 degradation and IL-4/IL-13 functional inhibition in human whole blood, were orally bioavailable in multiple preclinical species, and were able to deplete STAT6 in vivo.