2023年6月1日 · STIM1 and Orai1 are the central core of the Store Operated Calcium Entry (SOCE). This calcium influx mechanism is triggered after the activation of Gq protein-coupled receptors at the plasma membrane (PM) that activate phospholipase C.

Stromal interaction molecule 1 (STIM1), a well-established calcium (Ca 2+) sensor of endoplasmic reticulum (ER) Ca 2+ store, is increasingly recognized as a critical player in mediating both cardiac hypertrophy and diabetic cardiomyopathy. However, the cause–effect relationship between STIM1 and glucose/FA metabolism and the possible ...

2020年1月10日 · Formation of STIM1-TRPC1 interactions enable binding and activation of Gq and PLCβ1 activity, PIP 2 hydrolysis, DAG generation, stimulation PKCδ and PKC-dependent phosphorylation of TRPC1. This leads to dissociation of MARCKS from TRPC1 and release of PIP 2 (previously protected from PIP 2 hydrolysis) into the local environment where it acts ...

STIM1 and Orai1 are the central core of the Store Operated Calcium Entry (SOCE). This calcium influx mechanism is triggered after the activation of Gq protein-coupled receptors at the plasma membrane (PM) that activate phospholipase C.

2023年7月19日 · Imaging studies demonstrate that IP 3 Rs enhance association of STIM1 with Orai1 in neuronal cells with empty stores; this requires an IP 3-binding site, but not a pore. Convergent regulation by IP 3 Rs, may tune neuronal SOCE to respond selectively to receptors that generate IP 3.

Both Orai1- and Stim1-KD completely abrogated phenylephrine (PE) mediated hypertrophic NRCM growth and enhanced natriuretic factor expression by inhibiting G(q)-protein conveyed activation of the CamKII and ERK1/2 signalling pathway.

2021年3月1日 · STIM1 senses depletion of ER calcium stores and binds Orai-1 to allow entry of extracellular calcium. High intracellular calcium is pumped back into the ER by SERCA or out of the cell via PMCA. Pertussis toxin (PTX) ADP-ribosylates Gi-class alpha subunits to prevent G protein coupled receptor (GPCR) activation of Gi-signaling.

2021年12月23日 · Stromal interaction molecule 1 (Stim1) is the essential activator of store‐operated Ca 2+ entry (SOCE) triggering activation of transcription factors. Here, we characterize Stim1A, a splice variant with an additional 31 amino acid domain inserted in frame within its cytosolic domain.

2015年7月27日 · STIM1是免疫细胞中一种重要的内质网钙离子感受器，在机体对抗病原体过程中，STIM1蛋白感受到细胞内的钙离子变化，启动免疫细胞的开关，在免疫功能中起至关重要的作用。 近日，中科院强磁场科学中心王俊峰课题组与德州农工大学周育斌课题组、北京师范大学王友军课题组合作在STIM1蛋白的研究中取得进展，相关研究成果以“Inside-out Ca2+ signalling prompted by STIM1 conformational switch”为题发表在Nature Communications杂志上。 STIM1蛋白位于 …

STIM1 and Orai1 are the central core of the Store Operated Calcium Entry (SOCE). This calcium influx mechanism is triggered after the activation of Gq protein-coupled receptors at the plasma membrane (PM) that activate phospholipase C.