STIM2 protein is a type I transmembrane protein located in the S/ER. Human STIM2 consists of 833 amino acid residues (aas) (105-115 kDa) (Fig. 1), 148 additional aas compared to human STIM1. Their N-terminal regions share 66% similarity over 577 aas (85% of the amino acid sequence of STIM1).

2024年12月25日 · STIM2 (Stromal Interaction Molecule 2) is a Protein Coding gene. Diseases associated with STIM2 include T Cell And Nk Cell Immunodeficiency and Immunodeficiency 10. Among its related pathways are Myometrial relaxation and contraction pathways and Ca, cAMP and Lipid Signaling.

2012年8月23日 · Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of cellular calcium (Ca 2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they sense tiny changes...

An endoplasmic reticulum (ER)‐resident protein that regulates cytosolic and ER free‐Ca2+ concentration by induction of store‐operated calcium entry: that is the original definition of STIM2 and its function. While its activity strongly depends on ...

编码的蛋白质的功能是调节细胞质和内质网中的钙浓度，并参与质膜 Orai CA (2+) 进入通道的激活。 该基因从非 AUG (UUG) 起始位点开始翻译。 信号肽从产生的蛋白质上切下。 多个转录本变体由可变剪接产生。 [RefSeq 提供，2009 年 12 月] This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene.

2025年2月8日 · STIM2 is involved in spatial learning and plays an important role in ischemic-induced neuronal cell death during brain hypoxia. The absence of STIM2 reduces life expectancy in mice by sudden death. STIM2 regulates store-operated Ca2+ entry as a sensor of mild reductions in ER calcium levels.

2024年9月13日 · STIM2 was reported closely correlated with the function of immune cells via regulating Ca2+ signaling, energy metabolism and cell fitness. Herein, we sum the latest findings on the STIM2 structure, focusing on its distinct characteristics and profound effect on the regulation of Ca2+ homeostasis and multi-talented functionality.

最近的这个工作则进一步在SOAR区鉴定出了决定STIM结合Orai1能力强弱的关键位点（STIM1-G379/STIM2-E470），从而阐明了STIM特异性结合并激活Orai1的关键分子机制（PLOS Biology, 2018）。

2015年4月21日 · Stromal interaction molecule (STIM) proteins regulate store-operated calcium entry (SOCE) by sensing Ca 2+ concentration in the ER and forming oligomers to trigger Ca 2+ entry through...

2017年5月15日 · An endoplasmic reticulum (ER)-resident protein that regulates cytosolic and ER free-Ca 2+ concentration by induction of store-operated calcium entry: that is the original definition of STIM2 and its function. While its activity strongly depends on the amount of calcium stored in the ER, its function goes further, to intracellular signalling and ...