链脲佐菌素 (Streptozotocin，STZ)-糖尿病动物模型造模，糖尿病（diabetes mellitus ，DM）已成为严重危害人类健康的公共卫生问题。 DM及其并发症不仅严重影响糖尿病患者的生活质量， …

We have developed a robust and reproducible model of diabetes that combines exposure to a high-fat diet (HFD) with several sequential low doses of streptozotocin (STZ). HFD induce …

2024年8月2日 · Here, we develop a mouse model (Streptozotocin with high-fat diet, STZ + HFD) that gradually develops fatty liver, metabolic dysfunction-associated steatohepatitis (MASH), …

在1周的可调节喂养和4周的 HFD 喂养后，通过在0.1 M 柠檬酸盐缓冲液中腹膜内注射5天的低剂量链脲佐菌素(STZ; Sigma-Aldrich，St.Louis，MO，USA; 50mg/kg 体重)诱导 T2D,在注射 STZ …

2019年3月21日 · The HF-STZ group showed hyperglycemia after STZ administration (glucose on day 39: HF-STZ: 499 ± 60; control: 134 ± 9mg/dL). Serum glucagon was 23% lower, and …

In the present study, we will provide berberine to this model to evaluate whether it could cure the diabetes induced by high-fat diet combined with new models of multiple low-dose STZ injections.

We show that animals treated with STZ-high fat diet exhibit skin injuries without significant alterations on basal insulin and triglycerides, compared to the control. The skin from these …

2018年7月27日 · STZ-induced β–cell damage is an established model to study type 1 diabetes in rodents. High dose STZ induces hyperglycemia and leads to insulin deficiency resulting from …

The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that …

2021年12月1日 · C57BL/6 mice were treated with a high-fat diet (HFD), streptozotocin (STZ) and dexamethasone (DEX) at different doses and in combination. The general growth status, blood …