SV2A is a transmembrane protein of synaptic vesicles, ubiquitously expressed throughout the brain. The development of radiotracers that specifically target the protein proceeded from the …

2024年4月18日 · Synaptic vesicle glycoprotein 2a (SV2A), a putative membrane transporter in the synaptic vesicles (SVs), has been identified as a target of LEV and BRV....

2017年5月21日 · Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam …

We have identified SV2A as the binding site for the antiepileptic drug LEV and as a potential target for CNS therapy. Intriguingly, SV2A KO mice seem normal at birth, but develop an …

시냅스 소포 당단백질 2a, sv2a는 인간의 경우 2v2a 유전자가 암호화하는 시냅스 소포 단백질이다. [ 5 ] [ 6 ] [ 7 ] 이 단백질은 항간전제인 레비티라세탐 에 작용한다.

2021年6月30日 · Our results indicate that upregulation of SV2A decreases the relative expression level of AD-related genes. We found that Aβ expressions were significantly increased in …

通过敲除Sv2a基因的exon 3建立Sv2a基因敲除小鼠模型。 *使用本品系发表的文献需注明: Sv2a-KO (2) mice (Cat. NO. NM-KO-230023) were purchased from Shanghai Model Organisms …

2024年12月25日 · SV2A (Synaptic Vesicle Glycoprotein 2A) is a Protein Coding gene. Diseases associated with SV2A include Developmental And Epileptic Encephalopathy 113 and Epilepsy. …

2023年10月28日 · Single gene knockout (KO) experiments have shown that SV2A might regulate the size of the readily releasable pool of vesicles, as SV2A knockout resulted in reduced …

Here, we introduce a new chemogenetic approach for all-optical monitoring of excitation-secretion coupling, and we demonstrate its use in characterizing the SV2A knockout (KO) phenotype in …