2023年12月19日 · Our findings suggest that berberine improves stroke outcomes by modulating the gut microbiota. Specifically, after MCAO/R mice were given berberine, the beneficial bacteria producing butyric acid increased significantly, and the …

2021年1月26日 · Our data showed that nicorandil treatment could decrease brain damage, improve learning and memory, and increase SYP、GAP43 and NeuN level. Taken together, we propose that nicorandil, as an opener of the KATP channel, provides a neuroprotective role in MCAO by promoting synaptic connections.

2021年11月26日 · In this study, using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia/macrophages and astrocytes are differentially involved in engulfing synapses in the reactive...

<br> 本研究建立了大鼠脑缺血再灌注（MCAO）模型，通过神经学检查、TTC染色和透射电镜等进行模型鉴定。 为了探究BDNF-TrkB通路对脑卒中大鼠神经元突触可塑性的影响，通过RT-qPCR、Westernblotting和免疫组化方法在缺血再灌注损伤后的不同时间点检测BDNF-TrkB通路关键蛋白和突触可塑性标志物（SYP、PSD-95、MAP-2、GAP-43）的表达变化。 结果显示，损伤后BDNF在急性期内表达迅速增加，突触可塑性标志物减少，表明BDNF-TrkB信号通路的改变可直接影响 …

2021年3月1日 · This experiment showed that the expression of SYP and PSD was significantly reduced while NMDAR1 was aberrantly up-regulated in VD rats induced by MCAO/R. In terms of the critical role of synapses in cognitive ability, we studied the regulation of GJ-4 on synapses to elucidate the underlying mechanisms of improving learning and memory impairment.

2025年1月8日 · 中动脉闭塞（Middle cerebral artery occlusion, MCAO）模型是模拟脑梗死最常用的动物模型之一，通过阻断 大脑中动脉，造成大脑皮质和基底神经节区域的缺血，从而模拟人脑梗死的病理生理过程。 理解脑血管的解剖结构，特别是大脑中动脉的位置和分支， 对于成功制作MCAO模型至关重要。 此外，了解缺血性脑损伤的病理生理过程，例如兴奋性毒性、炎症反应和细胞凋亡，有助于你更好地理解实验结果。 线栓法制作MCAO模型的基本原理是通过手术将一 …

Minocycline prevents cognitive deficits via inhibiting mTOR signaling and enhancing the autophagy process, and promoting the expression of pre- and postsynaptic proteins (synaptophysin and PSD-95) in the brain of the MCAO stroke rats.

2021年1月18日 · Following the neurological function test, expression of synaptophysin (SYP) and growth-associated protein 43 (GAP-43) were analyzed through immunohistochemistry at 3 d, 7 d, 14 d, and 28 d after MCAO. Finally, the synaptic structural plasticity was investigated using transmission electron microscopy (TEM).

目的 观察电针心包经穴对局灶性脑缺血大鼠血清和脑组织突触素(syp)及突触后致密物-95(psd-95)表达的影响,探讨针刺对脑缺血后突触可塑性的作用机制.方法 将90只sd大鼠随机分为正常组、假手术组、模型组、心包经组、肺经组,每组再分为14、21、28 d 3个时间点,每个 ...

摘要： 目的 观察电针手厥阴心包经穴对大脑中动脉栓塞(MCAO)模型大鼠突触可塑性的影响,探讨其作用机制.方法 将150只SD大鼠随机分为正常组、假手术组、模型组、心包经组和肺经组,每组再分成3、7、14、21、28 d 5个时点,每个时点6只.采用颈外动脉插入线栓法制备 ...