2023年12月23日 · Specifically, we identify Saa3, a gene primarily expressed in macrophages, as a potent pro-inflammatory cytokine in SAKI. Saa3 hi Ccl2 hi monocyte-derived infiltrated macrophages (IMs) emerge as a central effector subset, fostering inflammation, and directly engaging with renal cells.

We report that the most differentially expressed gene, Saa3, a member of the serum amyloid A (SAA) apolipoprotein family, is a key mediator of the protumorigenic activity of PDGFRα + CAFs. Whereas Saa3 -competent CAFs stimulate the growth of tumor cells in an orthotopic model, Saa3 -null CAFs inhibit tumor growth.

2018年2月6日 · We report that the most differentially expressed gene, Saa3, a member of the serum amyloid A (SAA) apolipoprotein family, is a key mediator of the protumorigenic activity of PDGFRα + CAFs. Whereas Saa3 -competent CAFs stimulate the growth of tumor cells in an orthotopic model, Saa3 -null CAFs inhibit tumor growth.

Induced expression of SAA1 and SAA2 by hepatocytes contributes significantly to the rise of SAA in plasma during APR. Human SAA3 is a pseudogene, and human SAA4 encodes a protein that is constitutively produced . As a result, the inducible SAA isoforms (SAA1 and SAA2) are termed acute‐phase SAAs.

2018年11月8日 · Our findings indicate that endogenous SAA3 regulates lung development and homeostasis, and is required for protection against H1N1 influenza infection. Serum amyloid A (SAA) proteins were first...

2020年2月1日 · Understanding the host immune mechanisms against P. aeruginosa is, therefore, of clinical importance. The present study identified serum amyloid A3 (SAA3) as being highly inducible in mouse bronchial epithelium following P. aeruginosa infection.

2020年6月25日 · Serum amyloid A3 (Saa3) derives mainly from extrahepatic tissue and is not detected in plasma from moderately inflamed obese mice. In contrast, it is present in plasma from mice acutely...

2025年2月8日 · Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection. These results suggest that SAA3 plays a role in host innate immunity in the colon by up-regulating MUC2 mucin production, which builds a physiological barrier of colonic epithelia against bacterial invasion.

2015年3月4日 · The expression of mouse SAA3 (mSAA3) is known to be up-regulated extrahepatically in inflammatory responses, and acts as an endogenous ligand for the toll-like receptor 4/MD-2 complex. We previously reported that mSAA3 plays an important role in facilitating tumor metastasis by attracting circulating tumor cells and enhancing …

2024年5月1日 · We identified Saa3 is able to induce a shift in bone marrow-derived Mφ from M0 or M2 towards M1-like phenotype and this shift is characterized by an increase in M1-specific markers and cytokines production, alongside a reduction in M2-specific markers.