Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes [1][2][3] and is primarily used experimentally, to study stress responses in eukaryotic cells associated with …

Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation [1]. Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti …

Salubrinal是一种磷酸酶抑制剂，是eIF2α去磷酸化的选择性抑制剂，IC 50 为 15 μM，可抑制蛋白翻译，也能抑制ER应激诱导的细胞凋亡。 eIF2α磷酸化在蛋白质合成和细胞凋亡中有重要作 …

Salubrinal是一种选择性细胞复合体抑制剂，是真核翻译起始因子2亚基α (eIF2α)去磷酸化的抑制剂。 Salubrinal抑制蛋白糖基化抑制剂Tunicamycin (TM)诱导的ER应激介导的细胞凋亡，这种作 …

Salubrinal: 一种eIF2α inhibitors药物，由Harvard Medical School (Harvard Medical School)公司最早进行研发，目前全球最高研发状态为临床前，作用机制: eIF2α inhibitors(eukaryotic …

Salubrinal is a small molecular compound that specifically inhibits eIF2α phosphatase, mainly used to study the stress response of eukaryotic cells. Salubrinal recently opens a new way to …

Salubrinal 是 eIF2α 去磷酸化的选择性抑制剂（真核翻译起始因子 2α-亚单位），可抑制全局蛋白翻译。Salubrinal 是ER应激诱导细胞凋亡的特异性抑制剂。

2011年8月1日 · Salubrinal, a selective eukaryotic translation initiation factor 2 subunit α (eIF2α) dephosphorylation inhibitor, has been found to protect cells from endoplasmic reticulum (ER) …

Salubrinal作用于PC12细胞，快速且强效诱导eIF2α磷酸化及其下游效应，包括下调cyclin D1和上调GADD34和CHOP，eIF2α磷酸化诱导GADD34和CHOP这两种蛋白质的表达。 Salubrinal通 …

Salubrinal is a member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the …