2024年12月25日 · SAMM50 (SAMM50 Sorting And Assembly Machinery Component) is a Protein Coding gene. Diseases associated with SAMM50 include Glanders and Urethral Syndrome. Among its related pathways are Signaling by Rho GTPases and Transcriptional activation of mitochondrial biogenesis.

2022年3月27日 · Sam50（或 Samm50）是线粒体外膜中 β 桶蛋白组装所必需的分选和组装机器 (SAM) 的关键组成部分，可调节线粒体形态和嵴结构。 此外，Sam50 与 MICOS 复合物结合形成超复合物 BIM，它连接线粒体外膜和内膜。 有趣的是，Sam50 消耗会诱导 PINK1-Parkin 依赖性线粒体自噬，但会导致 mtDNA 聚集，从而保护 mtDNA 不被线粒体自噬移除。 此外，Sam50 基因的多态性与非酒精性脂肪肝的发生和进展显著相关。 然而，Sam50在调节mtDNA中的作用以 …

TOM70是最佳寄生虫生长所必需的，并使TgMAF1与线粒体外膜转位酶SAM50（分拣装配复合物的50 kDa亚基）之间发生相互作用，其中SAM50是线粒体外膜-内膜之间的线粒体膜间空间桥接（MIB）复合物的一个关键组成部分。 SAM50的基因切除和一种线粒体外膜靶向蛋白的过量表达诱导了SPOT样结构的形成，与感染无关。 综上所述，鉴于SAM50是线粒体输入复合物中唯一桥接线粒体外膜和线粒体内膜的成分，它能够将线粒体外膜应激转化为去除受损的线粒体外膜。 …

Ubiquitous expression in fat (RPKM 26.2), duodenum (RPKM 21.9) and 25 other tissues. 该基因编码线粒体外膜分选和组装机制 (SAM) 的一个组成部分。 Sam 复合体在将 β 桶蛋白组装到线粒体外膜中发挥作用。 [RefSeq 提供，2011 年 6 月] This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane.

SAM50, a 7-8 nm diameter β-barrel channel of the mitochondrial outer membrane, is the central channel of the sorting and assembly machinery (SAM) complex involved in the biogenesis of β-barrel proteins. Interestingly, SAM50 is not known to have channel translocase activity; however, we have recently …

Sam50 is a part of the sorting and assembly machinery (SAM) necessary for the assembly of β-barrel proteins in the OMM. We provide evidence that the SAM components exist in a large protein complex together with the IMM proteins mitofilin and CHCHD3, which we term the mitochondrial intermembrane space bridging (MIB) complex.

Our findings uncover the critical role of Sam50 in maintaining mitochondrial membrane integrity and mtDNA stability in hepatocytes and reveal that Sam50 depletion-induced cardiolipin externalization is a signal of mtDNA release and controls mtDNA-dependent innate immunity.

2020年7月3日 · We report cryoEM structures of the SAM complex from Myceliophthora thermophila, which show that Sam50 forms a 16-stranded transmembrane β-barrel with a single polypeptide-transport-associated...

2025年2月8日 · Sam50, the core component of the sorting and assembly machinery (SAM), is a critical regulator of mitochondrial dynamics and PINK1-Parkin-mediated mitophagy. The authors results demonstrate that SNP in the SAMM50 gene is significantly associated with the presence and severity of NAFLD in a Korean populations.

sam50 是线粒体外膜的 7-8 nm 直径 β-桶通道，是参与 β-桶蛋白生物发生的分选和组装机制 (sam) 复合体的中心通道。有趣的是，尚不知道 sam50 具有通道转位酶活性。然而，我们最近发现该通道对于细胞毒性蛋白酶进入线粒体是必要且充分的。