2024年12月25日 · SAP18 (Sin3A Associated Protein 18) is a Protein Coding gene. Diseases associated with SAP18 include Basal Cell Nevus Syndrome 1 and Pallister-Hall Syndrome. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and RNA Polymerase I Promoter Opening.

2023年7月24日 · Sin3 associated protein 18 (SAP18) is an evolutionary conserved protein, originally discovered in a complex with the transcriptional regulatory protein, Sin3. Subsequent investigations revealed SAP18 as an integral splicing component of the exon junction complex (EJC)-associated apoptosis-and splici …

2019年1月22日 · Here, we report that vFLIP facilitates cell migration, invasion, and angiogenesis by downregulating the SAP18-HDAC1 complex. vFLIP degrades SAP18 through a ubiquitin–proteasome pathway by...

SAP18（Sin3A-Associated Protein 18）是一种已知在人类细胞中与凋亡和剪接相关的蛋白质，其在植物中的功能却尚未完全了解。 在动物系统中，SAP18是ASAP（Apoptosis- and Splicing-Associated Protein）复合体的核心组成部分，与细胞凋亡和RNA剪接调控直接相关。

2006年10月3日 · The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. The solution structure of SAP18 reveals a ubiquitin-like fold with several large loop insertions relative to other family members.

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene. [5] [6]

2023年7月24日 · sin3 相关蛋白 18 (sap18) 是一种进化保守蛋白，最初是在与转录调节蛋白 sin3 的复合物中发现的。随后的研究表明 sap18 是外显子连接复合物 (ejc) 相关凋亡和剪接相关蛋白 (asap)/pnn-rnps1-sap18 (psap) 复合物的完整剪接组件。

该基因编码的蛋白质是组蛋白脱乙酰酶复合物的组成部分，包括 SIN3、SAP30、HDAC1、HDAC2、RbAp46、RbAp48 等多肽。 这种蛋白质直接与 SIN3 相互作用，并在连接到启动子时增强 SIN3 介导的转录抑制。 已在 2 号染色体上鉴定出一个假基因。 [RefSeq 提供，2008 年 12 月] Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes.

2025年1月13日 · Dynamic shuttling of proteins between the nucleus and cytoplasm orchestrates vital functions in eukaryotes. Here, we reveal the multifaceted functions of Arabidopsis Sin3-associated protein 18 kDa (SAP18) in the regulation of development and heat-stress tolerance.

2023年7月24日 · As a part of EJC, SAP18 mediates alternative splicing events and suppresses the cryptic splice sites present within flanking regions of exon–exon junctions. In this review, we provide a thorough discussion on SAP18, focussing on its conserved dual role in transcriptional regulation and messenger RNA splicing.