2024年12月25日 · SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Diseases associated with SAP30 include Phlebotomus Fever and Retinoblastoma. Among its related pathways are RNA Polymerase I Promoter Opening and Infectious disease. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity.

Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene. [5] Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes.

该基因编码的蛋白质是组蛋白脱乙酰酶复合物的组成部分，包括 SIN3、SAP18、HDAC1、HDAC2、RbAp46、RbAp48 等多肽。 该复合物对核心组蛋白八聚体去乙酰化具有活性，但对核小体组蛋白去乙酰化无活性。 该基因的假基因位于 3 号染色体上。 [RefSeq 提供，2008 年 7 月] Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes.

2024年12月25日 · SAP30BP (SAP30 Binding Protein) is a Protein Coding gene. Diseases associated with SAP30BP include Alveoli Adenoma and Bronchial Benign Neoplasm. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).

Reveal the correlation between hub hypoxia/immune-related genes and immunity and diagnosis, and the effect of SAP30 on cell apoptosis, ROS and MDA production in cerebral ischemic stroke. SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1.

2024年6月11日 · We found Sin3A-associated protein 30 (SAP30), a driver transcription factor positively associated with high-risk, progression, stage 4, and poor survival in neuroblastoma patient cohorts. Tumors of high-risk neuroblastoma patients and relapse-specific patient-derived xenografts showed higher SAP30 levels.

Here, we identify SAP30 as a novel component of the human histone deacetylase complex that includes Sin3, the histone deacetylases HDAC1 and HDAC2, histone binding proteins RbAp46 and RbAp48, as well as other polypeptides. Moreover, we describe a SAP30 homolog in yeast that is functionally related to Sin3 and the histone deacetylase Rpd3.

2024年12月25日 · Complete information for SAP30-DT gene (RNA Gene), SAP30 Divergent Transcript, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

中文名称：SAP30 结合蛋白. 种属: Homo sapiens. 同用名: HTRG; HTRP; HCNGP

1998年6月1日 · Here, we identify SAP30 as a novel component of the human histone deacetylase complex that includes Sin3, the histone deacetylases HDAC1 and HDAC2, histone binding proteins RbAp46 and RbAp48, as well as other polypeptides. Moreover, we describe a SAP30 homolog in yeast that is functionally related to Sin3 and the histone deacetylase Rpd3.