2008年3月19日 · SGX523 is selective inhibitor of the receptor tyrosine kinase MET. MET is implicated in development and progression of cancer. SGX523 ihibits MET autophosphorylation and signalling, as well as activates cysteine-aspartic acid protease 3 (caspase 3), an enzyme which is part of the apoptosis signalling cascade.

Here, we describe SGX523, a novel, ATP-competitive kinase inhibitor remarkable for its exquisite selectivity for MET. SGX523 potently inhibited MET with an IC50 of 4 nmol/L and is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays.

SGX523 is a drug which acts by blocking the function of an enzyme called MET. MET activity may be important in growth and survival of some types of cancer. This Phase I trial is studying the safety, side effects, and best dose of SGX523 when given to patients with advanced cancer, and how well it inhibits MET activity in tumors.

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USB4 通过 Intel Tunneled 相关技术可以同时传输 DisplayPort 影音和 PCIe 相关信号，并且支持 PD（Power Delivery）快充技术。 向下兼容 USB 2.0 和 USB 3.2 Gen1/Gen2，并支持 Thunderbolt 3/4。 Sideband 通道（SB）在 USB 3.2 中最初被定义为进入 Alt-Mode（Alternate Mode）模式后提供图像协议通信的通道（例如：DP Alt-Mode 通过 Sideband 通道传输 AUX 信号等）。 在 USB4 规格中，Sideband 通道新增功能用于确认 USB4 接口是否连接、通道的启动 …

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2019年2月17日 · （高清正版） asme sec ii b sb-523_sb-523m-2013 星级： 5 页 (正版） asme sec ii b sb-75-2013 星级： 11 页 asme sec viii d1 b pt ub 星级： 10 页 asme sec viii d1 b pt uf 星级： 9 页 asme sec viii d1 b pt uw ...