2024年12月25日 · SELP (Selectin P) is a Protein Coding gene. Diseases associated with SELP include Ige Responsiveness, Atopic and Intermittent Claudication. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Complement cascade.

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2025年2月3日 · P-selectin (SELP) expression in tumor cells has been implicated in promoting tumor progression and treatment resistance across various cancers. However, our prior study identified SELP expression in a specific subpopulation of endothelial cells within cervical cancer (CC) and potentially linked to a …

Broad expression in urinary bladder (RPKM 9.3), appendix (RPKM 7.3) and 20 other tissues. 该基因编码一种 140 kDa 的蛋白质，该蛋白质储存在血小板的 α 颗粒和内皮细胞的 Weibel-Palade 体中。 这种蛋白质在血小板活化和脱颗粒过程中重新分布到质膜，并介导活化的内皮细胞或血小板与白细胞的相互作用。 膜蛋白是一种钙依赖性受体，可与中性粒细胞和单核细胞上唾液酸化形式的 Lewis 血型碳水化合物抗原结合。 可能会出现替代剪接变体，但没有很好的记录。 [RefSeq 提 …

2025年2月25日 · 该研究深入探索了P-selectin (SELP) 在肿瘤内皮细胞 （Tumor endothelial cell, TECs） 中的作用，通过临床数据、单细胞RNA测序 （scRNA-seq） 、 空间转录组及bulk RNA-seq数据，揭示了SELP+TEC与CD8+ T细胞之间通过ACKR1-CCL5轴的相互作用在增强放疗效果中的关键作用。 本研究揭示了SELP通过调控免疫微环境增强宫颈癌放疗疗效的分子机理，主要发现包括： （1）SELP+ TECs与放疗预后改善相关：SELP高表达的TECs与接受放疗的宫颈癌患 …

P-selectin (SELP) and its ligand, P-selectin glycoprotein ligand 1 (SELPLG), play key roles in both the inflammatory response and the atherosclerotic process. Previous studies have shown genetic variation in the SELP gene [selectin P (granule ...

SELP is a comprehensive program that provides leadership development, technical hands-on experience, leadership and technical training, benchmarking, mentoring, and coaching. The program’s basis for design is founded in The Art and Science of Systems Engineering [ Full | Short ], the NASA Systems Engineering Behavior Study , and Behavior ...

Used to study acute necrotizing pancreatitis and anti-basement membrane glomerulonephritis. Biomarker of atherosclerosis; colitis; congestive heart failure; and myocardial infarction. Human ortholog (s) of this gene implicated in atopic dermatitis and myocardial infarction.

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