Dec 25, 2024 · SELP (Selectin P) is a Protein Coding gene. Diseases associated with SELP include Ige Responsiveness, Atopic and Intermittent Claudication. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Complement cascade.

P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5] P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel ...

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Feb 3, 2025 · P-selectin (SELP) expression in tumor cells has been implicated in promoting tumor progression and treatment resistance across various cancers. However, our prior study identified SELP expression in a specific subpopulation of endothelial cells within cervical cancer (CC) and potentially linked to a …

Mar 26, 2021 · We hypothesized that P-selectin (SELP), an adhesive molecule involved in leukocyte rolling, may represent one such immune-modulator.

Jun 1, 2020 · High expression of angiotensin-converting enzyme 2 receptor (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in platelets lead to thrombosis formation in COVID-19 patients.

P-selectin (SELP) and its ligand, P-selectin glycoprotein ligand 1 (SELPLG), play key roles in both the inflammatory response and the atherosclerotic process. Previous studies have shown genetic variation in the SELP gene [selectin P (granule ...

SELP haplotypes modulate plasma concentrations of sP-selectin and affect the risk of recurrent venous thromboembolism. associations between negative affect (i.e., depressive and anxious symptoms) with increased norepinephrine and P-selectin responses to …

Apr 13, 2024 · Clinical resource with information about SELP, Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease., Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease., Large-scale genomic studies reveal ...

P-selectin, an adhesion molecule, is encoded by SELP and known as biomarker of endothelial as well as platelet dysfunction. SELP polymorphisms (rs6136, rs6127, and rs6125) and raised levels of soluble P-selectin (sP-selectin) have been associated with several disease conditions.