Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (C luster of D ifferentiation 108), is a human gene. [5] SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage.

2024年4月24日 · 可溶性SEMA7A分别通过诱导T-bet和RORγt表达促进CD4+T分化为Th1和Th17两种亚型，并可启动T细胞介导的炎症反应。 在胃肠道炎症中，SEMA7局部表达升高，对其敲除可以恢复TGFβ信号从而减轻炎症程度。

2024年12月25日 · SEMA7A (Semaphorin 7A (JohnMiltonHagen Blood Group)) is a Protein Coding gene. Diseases associated with SEMA7A include Cholestasis, Progressive Familial Intrahepatic, 11 and Blood Group, John Milton Hagen System. Among its related pathways are Nervous system development and Semaphorin interactions.

2020年8月10日 · Semaphorin7A (Sema7A) has been reported to regulate nerve and vessel homeostasis, but its role in EndMT remains unclear. Here we investigate the effect of Sema7A on EndMT and the underlying...

2003年7月24日 · Unlike many other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic...

2017年3月10日 · Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on...

Sema7A是迄今为止Sema家族中唯一一个与糖基化磷脂酰肌醇（glycosylphosphatidylinositol，GPI）相偶联的膜相关糖蛋白。 Sema7A主要通过与受体神经丛蛋白C1和整合素α1β1结合而发挥作用。

在其家族的8个亚群中，SEMA7A是唯一的膜结合型糖基化磷脂酰肌醇（glycosylphosphatidylinostol， GPI）结合蛋白。 SEMA7A多表达于活化的T细胞表面。 目前已知其有2种受体，受体神经丛蛋白C1（plexin C1）表达于DC、单核细胞和中性粒细胞表面，而整合素α1β1（integrin α1β1 ...

2025年2月8日 · Title: A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear Cell Carcinoma. Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.

该基因编码信号素蛋白家族的成员。 编码的前原蛋白经过蛋白水解处理，生成成熟的糖基磷脂酰肌醇 (GPI) 锚定膜糖蛋白。 编码的蛋白质存在于活化的淋巴细胞和红细胞上，可能参与免疫调节和神经元过程。 编码的蛋白质携带 John Milton Hagen (JMH) 血型抗原。 该基因的突变可能与骨矿物质密度 (BMD) 降低有关。 可变剪接导致多个转录本变体，其中至少一个编码一种经过蛋白水解处理的亚型。 [RefSeq 提供，2016 年 2 月] This gene encodes a member of the semaphorin …