Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the …

分离酶 （Separase）是一种半胱氨酸蛋白酶，是所有真核细胞分裂末期过渡的触发因子，具有类似 caspase 的催化结构域，但以前从未发现与细胞凋亡过程有关 【1,2】。 细胞分裂周期延 …

Separase is a large cysteine protease, with an N-terminal helical region, a C-terminal catalytic region, and an unstructured regulatory segment in between. Separase has diverse functions …

Separase, by irreversible cleavage of cohesin complex subunit, paves the way for metaphase/anaphase transition during the cell cycle. Both over or reduced expression and …

2016年3月30日 · Separase is absolutely essential for cohesion dissolution in organisms from yeast to man1,2. It cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow …

Separase is a large cysteine protease in eukaryotes and has crucial roles in many cellular processes, especially chromosome segregation during mitosis and meiosis, apoptosis, DNA …

Separase is a protease that degrades the cohesin rings that link the two sister chromatids together. You might find these chapters and articles relevant to this topic. Separase is a large …

separase 定 义 有丝分裂后期催化粘连蛋白分解，导致姐妹染色单体分离的酶。 应用学科 细胞生物学（一级学科），细胞周期与细胞分裂（二级学科）

Separase is a protease that is essential for mitotic progression. At the metaphase-to-anaphase transition, separase dissolves the cohesion between sister chromatids, allowing the …

2024年11月18日 · Separase regulates multiple aspects of the metaphase-to-anaphase transition. Separase cleaves cohesin to allow chromosome segregation and localizes to vesicles to …