Sepsis—Pathophysiology and Therapeutic Concepts - PMC
Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology.
Bacterial Sepsis - StatPearls - NCBI Bookshelf
2023年5月21日 · Review the pathophysiology of bacterial sepsis. Describe the typical lab findings in bacterial sepsis. Summarize the components of the acute sepsis bundle and the components of the sepsis management bundle used in the evaluation and treatment of patients with sepsis.
Sepsis: The evolution in definition, pathophysiology, and …
Sepsis is a medical emergency that describes the body’s systemic immunological response to an infectious process that can lead to end-stage organ dysfunction and death.
Pathophysiology of sepsis - UpToDate
Sepsis results when the response to infection becomes generalized and involves normal tissues remote from the site of injury or infection. The pathophysiology of sepsis and mechanisms of multiple organ system dysfunction are reviewed here. The definition and management of sepsis are discussed separately.
Sepsis - Symptoms & causes - Mayo Clinic
2023年2月10日 · Sepsis is a serious condition in which the body responds improperly to an infection. The infection-fighting processes turn on the body, causing the organs to work poorly. Sepsis may progress to septic shock.
PATHOPHYSIOLOGY OF SEPSIS… The pathophysiology of sepsis is complex and results from the effects of circulating bacterial products, mediated by cytokine release, caused by sustained bacteraemia. Cytokines are primarily responsible for the clinically observable effects of the bacteraemia in the host.
The Pathogenesis of Sepsis - PMC - PubMed Central (PMC)
Sepsis is a serious clinical condition that represents a patient’s response to a severe infection and has a very high mortality rate. Normal immune and physiologic responses eradicate pathogens, and the pathophysiology of sepsis is due to the inappropriate regulation of these normal reactions.
Pathophysiology of sepsis - PubMed
2021年4月1日 · Sepsis represents a dysregulated host response to infection leading to organ dysfunction. Here, the pathogen triggers an initial exaggerated inflammatory-immune response that leads to activation or suppression of multiple endothelial, hormonal, bioenergetic, metabolic, immune, and other pathways.
Advances in unraveling the pathophysiolo-gy and genetic basis for the host response to sepsis have changed the prevailing under-standing of the syndrome, and several therapies have demonstrated surprising effica-cy. In this article, we examine evolving concepts of sepsis and discuss new and potential therapies.
Pathophysiology of sepsis - UpToDate
2024年11月1日 · Sepsis results when the response to infection becomes generalized and involves normal tissues remote from the site of injury or infection. The pathophysiology of sepsis and mechanisms of multiple organ system dysfunction are reviewed here.