An expedient and mild method for the direct conversion of aldehydes to 2,4-disubstituted oxazoles relies on the oxidation of an oxazolidine formed from the condensation of serine with an …

There are three methyloxazoles, one oxazole, and two thiazoles, indicating heterocyclization of three Thr, one Ser, and two Cys residues during posttranslational maturation. There are also …

In both serine-to-oxazole and cysteine-to-thiazole transformation for MccB17, and most likely for all such peptide-derived natural products (for example, Fig. 1), we propose a three-step …

2011年1月7日 · Herein, we report on the preparation and full characterization of some new carboxy thiazole (oxazole)-based ligands using a simple synthetic approach, which starts from …

In biomolecules, oxazoles result from the cyclization and oxidation of serine or threonine nonribosomal peptides: [5] Where X = H, CH 3 for serine and threonine respectively, B = base. …

2011年6月1日 · The biosynthesis and structure of thiazole/oxazole containing compounds. (a) Thiazoles and oxazoles are installed by peptide backbone cyclodehydration of a cysteine, …

2010年12月29日 · The phorboxazoles are mixed non-ribosomal peptide synthase/polyketide synthase biosynthetic products that embody polyketide domains joined via two serine-derived …

2011年1月1日 · Oxazoles are a class of heterocyclic compounds that are believed to occur in nature from post-translational modification of serine and threonine residues in peptides. They …

2020年5月1日 · The synthesis of 19 compounds derived from l-serine and analogs of p-substituted cinnamic acid is reported. Oxazolines 9 and oxazoles 10 have high antitubercular …

2018年10月29日 · Amino acid-based oxazoles and thiazoles are formed from the cyclization of serine, threonine, and cysteine side chains onto the peptide backbone and are common …