Sestrin-2 also known as Hi95 is a protein that in humans is encoded by the SESN2 gene. [5][6][7] This gene encodes a member of the sestrin family of PA26 -related proteins. The encoded protein may function in the regulation of cell growth and survival.

2020年11月23日 · Sestrin mediated reduced intestinal stem cell activity and gut cell turnover from DR, and stem cell proliferation in response to dietary amino acids, by regulating the TOR pathway and...

Sestrins是一个应激诱导蛋白家族，在疾病或应激状态下表达升高，发挥抑炎、抗氧化、抗衰老等功能，但其具体分子机制和信号通路比较复杂。本文总结了过去几年对于sestrin的相关研究，结合它的分子结构分析其具体功能及最新研究进展。

2018年11月12日 · 近年来，关于Sestrins信号及其分子性质的研究已有突破性发现，揭示了衰老和年龄相关退行性病变新的潜在的治疗方向。 本文就Sestrins在调控衰老中的作用研究进展进行综述。 Medical Research Center, Shengjing Hospital, China Medical University, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shenyang 110004, China.

2023年2月25日 · SESN2 is a stress-responsive protein with a distinct molecular structure regulating mTORC1. SESN2 is involved in multiple pathophysiological events, such as hypoxia, genotoxic stress, oxidative...

Sestrins are a family of stress-responsive antioxidant proteins responsible for regulation of cell viability and metabolism. The best known Sestrin targets are mTORC1 and mTORC2 kinases that control different cellular processes including growth, …

2024年7月30日 · Growing evidences proved sestrin proteins exert protective functions in cardiovascular diseases, chronic degenerative osteoarthritis, musculoskeletal diseases, aging and others, sestrin proteins exhibit an anti-inflammatory response, improving metabolism and other valuable character.

Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, endoplasmic reticulum (ER) stress, and hypoxia.

Sestrins是一类高度保守的应激诱导蛋白,通过多种机制保护细胞免受应激、老化等病理生理因素损伤。 Sestrin2 (Sesn2)是Sestrins蛋白亚型,缺氧、氧化应激等可诱导其表达,Sesn2参与代谢相关性和年龄相关性疾病的病理过程,也参与细胞生长和代谢的调节,与细胞功能密切相关。 细胞免疫功能 …

2022年1月3日 · Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect organisms against various noxious stimuli including DNA damage, oxidative stress, starvation, endoplasmic reticulum (ER) stress, and hypoxia.