SGLT-2抑制剂，中文名为钠-葡萄糖协同转运蛋白2 (sodium-dependent glucose transporters 2，SGLT-2)抑制剂，可以抑制肾脏对葡萄糖的重吸收，使过量的葡萄糖从尿液中排出，降低血糖。 这是一类新型抗糖尿病药物。 钠-葡萄糖协同转运蛋白2 (sodium-dependent glucose transporters 2，SGLT-2)抑制剂可以抑制肾脏对葡萄糖的重吸收，使过量的葡萄糖从尿液中排出，降低血糖。 为糖尿病的治疗提供了一条新的途径，成为降糖药物研究的热点。 肾脏在机体糖代谢方面发 …

Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa (enterocytes) of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST).

2020年3月2日 · Empaglifolzin, canagliflozin, and dapagliflozin are SGLT2 (sodium-glucose linked transporter type 2) inhibitors for treatment of type 2 diabetes mellitus that also reduce blood pressure, mortality, and cardiovascular disease and slow the loss of glomerular filtration rate.

2023年6月3日 · Sodium-glucose cotransporter 2 (SGLT-2) inhibitors act on the SGLT proteins expressed in the proximal renal convoluted tubules. Four agents (canagliflozin, dapagliflozin, empagliflozin, ertugliflozin) are FDA-approved for managing adult patients with type 2 diabetes mellitus (DM) to improve blood sugar control adjunct to diet and exercise.

2023年5月30日 · SGLT-2 inhibitors are a class of medicine used to lower high blood glucose levels in people with type 2 diabetes. They may also be called gliflozins. SGLT-2 inhibitors inhibit SGLT-2 proteins located in the renal tubules of the kidneys which are responsible for reabsorbing glucose back into the blood.

Because of glucose excretion, these drugs lower plasma glucose and glycosylated hemoglobin levels in patients with type 2 diabetes mellitus. The drugs also protect against heart and renal failure. The aim of this review is to summarize what is known about the physiology of renal SGLTs and the pharmacology of SGLT drugs.

2023年3月16日 · SGLT2 inhibitors were developed to lower blood sugar in type 2 diabetes. But they do have other uses. Some of them are approved for chronic kidney disease. They also can treat heart failure.

2021年1月，英国临床糖尿病专家协会(abcd)联合英国糖尿病联合会共同发布了非糖尿病专科医生应用sglt2抑制剂治疗2型糖尿病的建议。钠葡萄糖共转运体2（sglt2）抑制剂是目前公认的治疗2型糖尿

2021年7月16日 · SGLT-2i主要通过抑制肾小管SGLT2，降低肾糖阈，减少尿液中葡萄糖的重吸收，促进尿葡萄糖排泄，从而降低血液循环中葡萄糖的水平。 SGLT-2i作用机制独特，不依赖于胰腺β细胞的功能，也与胰岛素抵抗的程度无关。 目前在我国上市的SGLT-2i有达格列净、恩格列净、卡格列净和艾托格列净。 具体用法用量见下表，如漏服，建议患者在想起后尽快服用，不得在同一天服用两次SGLT-2i。 表1 SGLT-2i的服用方法. 起始剂量5 mg，每日一次，晨服，不受进食 …

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